IDEAS home Printed from https://ideas.repec.org/a/eee/jmvana/v105y2012i1p397-411.html
   My bibliography  Save this article

Principled sure independence screening for Cox models with ultra-high-dimensional covariates

Author

Listed:
  • Zhao, Sihai Dave
  • Li, Yi

Abstract

It is rather challenging for current variable selectors to handle situations where the number of covariates under consideration is ultra-high. Consider a motivating clinical trial of the drug bortezomib for the treatment of multiple myeloma, where overall survival and expression levels of 44760 probesets were measured for each of 80 patients with the goal of identifying genes that predict survival after treatment. This dataset defies analysis even with regularized regression. Some remedies have been proposed for the linear model and for generalized linear models, but there are few solutions in the survival setting and, to our knowledge, no theoretical support. Furthermore, existing strategies often involve tuning parameters that are difficult to interpret. In this paper, we propose and theoretically justify a principled method for reducing dimensionality in the analysis of censored data by selecting only the important covariates. Our procedure involves a tuning parameter that has a simple interpretation as the desired false positive rate of this selection. We present simulation results and apply the proposed procedure to analyze the aforementioned myeloma study.

Suggested Citation

  • Zhao, Sihai Dave & Li, Yi, 2012. "Principled sure independence screening for Cox models with ultra-high-dimensional covariates," Journal of Multivariate Analysis, Elsevier, vol. 105(1), pages 397-411.
    • Handle: RePEc:eee:jmvana:v:105:y:2012:i:1:p:397-411
    DOI: 10.1016/j.jmva.2011.08.002
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0047259X11001618
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.jmva.2011.08.002?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Zou, Hui, 2006. "The Adaptive Lasso and Its Oracle Properties," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 1418-1429, December.
    2. Hao Helen Zhang & Wenbin Lu, 2007. "Adaptive Lasso for Cox's proportional hazards model," Biometrika, Biometrika Trust, vol. 94(3), pages 691-703.
    3. Tibshirani Robert J., 2009. "Univariate Shrinkage in the Cox Model for High Dimensional Data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 8(1), pages 1-18, April.
    4. Jianqing Fan & Jinchi Lv, 2008. "Sure independence screening for ultrahigh dimensional feature space," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 70(5), pages 849-911, November.
    5. Fan J. & Li R., 2001. "Variable Selection via Nonconcave Penalized Likelihood and its Oracle Properties," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 1348-1360, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Guang Cheng & Hao Zhang & Zuofeng Shang, 2015. "Sparse and efficient estimation for partial spline models with increasing dimension," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 67(1), pages 93-127, February.
    2. Jing Zhang & Guosheng Yin & Yanyan Liu & Yuanshan Wu, 2018. "Censored cumulative residual independent screening for ultrahigh-dimensional survival data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(2), pages 273-292, April.
    3. Jing Zhang & Haibo Zhou & Yanyan Liu & Jianwen Cai, 2021. "Conditional screening for ultrahigh-dimensional survival data in case-cohort studies," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 27(4), pages 632-661, October.
    4. Liu, Yanyan & Zhang, Jing & Zhao, Xingqiu, 2018. "A new nonparametric screening method for ultrahigh-dimensional survival data," Computational Statistics & Data Analysis, Elsevier, vol. 119(C), pages 74-85.
    5. Shan Luo & Zehua Chen, 2014. "Sequential Lasso Cum EBIC for Feature Selection With Ultra-High Dimensional Feature Space," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 109(507), pages 1229-1240, September.
    6. Shi Chen & Wolfgang Karl Hardle & Brenda L'opez Cabrera, 2020. "Regularization Approach for Network Modeling of German Power Derivative Market," Papers 2009.09739, arXiv.org.
    7. Wang, Christina Dan & Chen, Zhao & Lian, Yimin & Chen, Min, 2022. "Asset selection based on high frequency Sharpe ratio," Journal of Econometrics, Elsevier, vol. 227(1), pages 168-188.
    8. Peter Bühlmann & Jacopo Mandozzi, 2014. "High-dimensional variable screening and bias in subsequent inference, with an empirical comparison," Computational Statistics, Springer, vol. 29(3), pages 407-430, June.
    9. Anders Bredahl Kock, 2012. "On the Oracle Property of the Adaptive Lasso in Stationary and Nonstationary Autoregressions," CREATES Research Papers 2012-05, Department of Economics and Business Economics, Aarhus University.
    10. Loann David Denis Desboulets, 2018. "A Review on Variable Selection in Regression Analysis," Econometrics, MDPI, vol. 6(4), pages 1-27, November.
    11. Li, Xinyi & Wang, Li & Nettleton, Dan, 2019. "Sparse model identification and learning for ultra-high-dimensional additive partially linear models," Journal of Multivariate Analysis, Elsevier, vol. 173(C), pages 204-228.
    12. Lee, Ji Hyung & Shi, Zhentao & Gao, Zhan, 2022. "On LASSO for predictive regression," Journal of Econometrics, Elsevier, vol. 229(2), pages 322-349.
    13. Medeiros, Marcelo C. & Mendes, Eduardo F., 2016. "ℓ1-regularization of high-dimensional time-series models with non-Gaussian and heteroskedastic errors," Journal of Econometrics, Elsevier, vol. 191(1), pages 255-271.
    14. Lian, Heng & Li, Jianbo & Hu, Yuao, 2013. "Shrinkage variable selection and estimation in proportional hazards models with additive structure and high dimensionality," Computational Statistics & Data Analysis, Elsevier, vol. 63(C), pages 99-112.
    15. Hu Yang & Ning Li & Jing Yang, 2020. "A robust and efficient estimation and variable selection method for partially linear models with large-dimensional covariates," Statistical Papers, Springer, vol. 61(5), pages 1911-1937, October.
    16. Chen, Shi & Härdle, Wolfgang Karl & López Cabrera, Brenda, 2018. "Regularization Approach for Network Modeling of German Energy Market," IRTG 1792 Discussion Papers 2018-017, Humboldt University of Berlin, International Research Training Group 1792 "High Dimensional Nonstationary Time Series".
    17. Zakariya Yahya Algamal & Muhammad Hisyam Lee, 2019. "A two-stage sparse logistic regression for optimal gene selection in high-dimensional microarray data classification," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 13(3), pages 753-771, September.
    18. He, Yong & Zhang, Liang & Ji, Jiadong & Zhang, Xinsheng, 2019. "Robust feature screening for elliptical copula regression model," Journal of Multivariate Analysis, Elsevier, vol. 173(C), pages 568-582.
    19. Na You & Shun He & Xueqin Wang & Junxian Zhu & Heping Zhang, 2018. "Subtype classification and heterogeneous prognosis model construction in precision medicine," Biometrics, The International Biometric Society, vol. 74(3), pages 814-822, September.
    20. T. Cai & J. Huang & L. Tian, 2009. "Regularized Estimation for the Accelerated Failure Time Model," Biometrics, The International Biometric Society, vol. 65(2), pages 394-404, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:jmvana:v:105:y:2012:i:1:p:397-411. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/wps/find/journaldescription.cws_home/622892/description#description .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.