IDEAS home Printed from https://ideas.repec.org/a/eee/intell/v98y2023ics0160289623000296.html
   My bibliography  Save this article

Gene-environment interplay in early life cognitive development

Author

Listed:
  • von Stumm, Sophie
  • Kandaswamy, Radhika
  • Maxwell, Jessye

Abstract

Children's differences in early life cognitive development are driven by the interplay of genetic and environmental factors, but identifying replicable gene-environment interactions (GxE) has proven difficult. We systematically tested GxE effects in the prediction of cognitive development from 2 to 4 years, using polygenic scores (PGS) for years spent in education and 39 measures of the home and neighborhood environment. Data came from up to 6973 unrelated individuals from the Twins Early Development Study (TEDS), a UK population-representative cohort. The environmental measures accounted together for 20.6% of the variance in cognitive development, while the PGS accounted for 0.5% (p < .001). We observed substantial gene-environment correlations but found no conclusive evidence for GxE effects. While associations between PGS and cognitive development were weak, genetic and environmental factors had direct and additive (i.e., main effects) rather than interactive influences on early life cognitive development.

Suggested Citation

  • von Stumm, Sophie & Kandaswamy, Radhika & Maxwell, Jessye, 2023. "Gene-environment interplay in early life cognitive development," Intelligence, Elsevier, vol. 98(C).
    • Handle: RePEc:eee:intell:v:98:y:2023:i:c:s0160289623000296
    DOI: 10.1016/j.intell.2023.101748
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0160289623000296
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.intell.2023.101748?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Abdel Abdellaoui & David Hugh-Jones & Loic Yengo & Kathryn E. Kemper & Michel G. Nivard & Laura Veul & Yan Holtz & Brendan P. Zietsch & Timothy M. Frayling & Naomi R. Wray & Jian Yang & Karin J. H. Ve, 2019. "Genetic correlates of social stratification in Great Britain," Nature Human Behaviour, Nature, vol. 3(12), pages 1332-1342, December.
    2. Ken B Hanscombe & Maciej Trzaskowski & Claire M A Haworth & Oliver S P Davis & Philip S Dale & Robert Plomin, 2012. "Socioeconomic Status (SES) and Children's Intelligence (IQ): In a UK-Representative Sample SES Moderates the Environmental, Not Genetic, Effect on IQ," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-16, February.
    3. Victor Ronda & Esben Agerbo & Dorthe Bleses & Preben Bo Mortensen & Anders Børglum & Ole Mors & Michael Rosholm & David M. Hougaard & Merete Nordentoft & Thomas Werge, 2022. "Family disadvantage, gender, and the returns to genetic human capital," Scandinavian Journal of Economics, Wiley Blackwell, vol. 124(2), pages 550-578, April.
    4. Brendan Maher, 2008. "Personal genomes: The case of the missing heritability," Nature, Nature, vol. 456(7218), pages 18-21, November.
    5. Teri A. Manolio & Francis S. Collins & Nancy J. Cox & David B. Goldstein & Lucia A. Hindorff & David J. Hunter & Mark I. McCarthy & Erin M. Ramos & Lon R. Cardon & Aravinda Chakravarti & Judy H. Cho &, 2009. "Finding the missing heritability of complex diseases," Nature, Nature, vol. 461(7265), pages 747-753, October.
    6. Leon Feinstein, 2003. "Inequality in the Early Cognitive Development of British Children in the 1970 Cohort," Economica, London School of Economics and Political Science, vol. 70(277), pages 73-97, February.
    7. Rosseel, Yves, 2012. "lavaan: An R Package for Structural Equation Modeling," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 48(i02).
    8. Andrea G Allegrini & Ville Karhunen & Jonathan R I Coleman & Saskia Selzam & Kaili Rimfeld & Sophie von Stumm & Jean-Baptiste Pingault & Robert Plomin, 2020. "Multivariable G-E interplay in the prediction of educational achievement," PLOS Genetics, Public Library of Science, vol. 16(11), pages 1-20, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Pereira, Rita & Biroli, Pietro & von hinke, stephanie & Van Kippersluis, Hans & Galama, Titus & Rietveld, Niels & Thom, Kevin, 2022. "Gene-Environment Interplay in the Social Sciences," OSF Preprints d96z3, Center for Open Science.
    2. Andrea G Allegrini & Ville Karhunen & Jonathan R I Coleman & Saskia Selzam & Kaili Rimfeld & Sophie von Stumm & Jean-Baptiste Pingault & Robert Plomin, 2020. "Multivariable G-E interplay in the prediction of educational achievement," PLOS Genetics, Public Library of Science, vol. 16(11), pages 1-20, November.
    3. Lucas Alvizi & Diogo Nani & Luciano Abreu Brito & Gerson Shigeru Kobayashi & Maria Rita Passos-Bueno & Roberto Mayor, 2023. "Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene–environment interaction," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Young Lee & Suyeon Park & Sanghoon Moon & Juyoung Lee & Robert C. Elston & Woojoo Lee & Sungho Won, 2014. "On the Analysis of a Repeated Measure Design in Genome-Wide Association Analysis," IJERPH, MDPI, vol. 11(12), pages 1-21, November.
    5. Md. Mominur Rahman & Bilkis Akhter, 2021. "The impact of investment in human capital on bank performance: evidence from Bangladesh," Future Business Journal, Springer, vol. 7(1), pages 1-13, December.
    6. César Merino-Soto & Gina Chávez-Ventura & Verónica López-Fernández & Guillermo M. Chans & Filiberto Toledano-Toledano, 2022. "Learning Self-Regulation Questionnaire (SRQ-L): Psychometric and Measurement Invariance Evidence in Peruvian Undergraduate Students," Sustainability, MDPI, vol. 14(18), pages 1-17, September.
    7. Michael Marmot & Ruth Bell & Angela Donkin, 2013. "Tackling Structural and Social Issues to Reduce Inequities in Children’s Outcomes in Low- to Middle-income Countries," Papers indipa708, Innocenti Discussion Papers.
    8. Nathaniel Oliver Iotti & Damiano Menin & Tomas Jungert, 2022. "Early Adolescents’ Motivations to Defend Victims of Cyberbullying," IJERPH, MDPI, vol. 19(14), pages 1-9, July.
    9. Andreea-Ionela Puiu & Anca Monica Ardeleanu & Camelia Cojocaru & Anca Bratu, 2021. "Exploring the Effect of Status Quo, Innovativeness, and Involvement Tendencies on Luxury Fashion Innovations: The Mediation Role of Status Consumption," Mathematics, MDPI, vol. 9(9), pages 1-18, May.
    10. Allen, Jaime & Muñoz, Juan Carlos & Ortúzar, Juan de Dios, 2019. "On evasion behaviour in public transport: Dissatisfaction or contagion?," Transportation Research Part A: Policy and Practice, Elsevier, vol. 130(C), pages 626-651.
    11. Merkle, Edgar C. & Steyvers, Mark & Mellers, Barbara & Tetlock, Philip E., 2017. "A neglected dimension of good forecasting judgment: The questions we choose also matter," International Journal of Forecasting, Elsevier, vol. 33(4), pages 817-832.
    12. Sai-fu Fung & Esther Oi-wah Chow & Chau-kiu Cheung, 2020. "Development and Evaluation of the Psychometric Properties of a Brief Wisdom Development Scale," IJERPH, MDPI, vol. 17(8), pages 1-14, April.
    13. Dang Vu, Hoai Nam & Nielsen, Martin Reinhardt, 2022. "Understanding determinants of the intention to buy rhino horn in Vietnam through the Theory of Planned Behaviour and the Theory of Interpersonal Behaviour," Ecological Economics, Elsevier, vol. 195(C).
    14. Georges Steffgen & Philipp E. Sischka & Martha Fernandez de Henestrosa, 2020. "The Quality of Work Index and the Quality of Employment Index: A Multidimensional Approach of Job Quality and Its Links to Well-Being at Work," IJERPH, MDPI, vol. 17(21), pages 1-31, October.
    15. Zaitun Mohd Saman & Ab Hamid Siti-Azrin & Azizah Othman & Yee Cheng Kueh, 2021. "The Validity and Reliability of the Malay Version of the Cyberbullying Scale among Secondary School Adolescents in Malaysia," IJERPH, MDPI, vol. 18(21), pages 1-12, November.
    16. Menta, Giorgia & Lepinteur, Anthony & Clark, Andrew E. & Ghislandi, Simone & D'Ambrosio, Conchita, 2023. "Maternal genetic risk for depression and child human capital," Journal of Health Economics, Elsevier, vol. 87(C).
    17. Dennis Cook, R. & Forzani, Liliana, 2023. "On the role of partial least squares in path analysis for the social sciences," Journal of Business Research, Elsevier, vol. 167(C).
    18. Lindsey Macmillan & Emma Tominey, 2023. "Parental inputs and socio-economic gaps in early child development," Journal of Population Economics, Springer;European Society for Population Economics, vol. 36(3), pages 1513-1543, July.
    19. Castaldo, Sandro & Ciacci, Andrea & Penco, Lara, 2023. "Perceived corporate social responsibility and job satisfaction in grocery retail: A comparison between low- and high-productivity stores," Journal of Retailing and Consumer Services, Elsevier, vol. 74(C).
    20. Daniel Hoppe, 2021. "Argument-Based Versus Emotion-Based Videos During the Early Stages of Recruitment: Effects on Perceived Employer Brand Image, Application Intentions, and Positive Word-of-Mouth," Corporate Reputation Review, Palgrave Macmillan, vol. 24(1), pages 31-47, February.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:intell:v:98:y:2023:i:c:s0160289623000296. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: https://www.journals.elsevier.com/intelligence .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.