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The Use of Some Selected Antioxidant Supplements in the Management of Fluoride Toxicity on Adult Male Wistar Rats’ Fecundity

Author

Listed:
  • Anacletus F. C.

    (Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria)

  • Onyegeme-Okerenta B. M.

    (Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria)

  • Iheka C.U.

    (Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria)

Abstract

The use of ameliorative antioxidant potentials of some selected antioxidant supplements in the management of fluoride toxicity on adult male Wistar rats’ fecundity was investigated. Thirty-six adult male albino rats were divided into 6 groups. Group I (positive control) received oral dose of normal feed and water for 4 weeks and 6 weeks, Group II (negative control) sodium fluoride (10mg/kg) body weight (b.w), Group III received sodium fluoride (10mg/kg) + selenium(0.5mg/kg) b.w, Group IV sodium fluoride (10mg/kg) + zinc (14.8mg/kg) b.w, Group V sodium fluoride (10mg/kg) + ginseng (10mg/kg) b.w, Group VI sodium fluoride (10mg/kg) + vitamin E (100mg/kg) b.w. At the end of the 4th and 6th week, hormone assay: (testosterone, prolactin, luteinizing hormone and follicle stimulating hormone, sperm quality analysis: morphology, motility, abnormality, sluggishness, deadness and sperm count) were analysed. Result showed that Group 11 had a significant decrease (p

Suggested Citation

  • Anacletus F. C. & Onyegeme-Okerenta B. M. & Iheka C.U., 2016. "The Use of Some Selected Antioxidant Supplements in the Management of Fluoride Toxicity on Adult Male Wistar Rats’ Fecundity," Journal of Biotechnology Research, Academic Research Publishing Group, vol. 2(3), pages 12-23, 03-2016.
    • Handle: RePEc:arp:rjbarp:2016:p:12-23
    DOI: arpgweb.com/?ic=journal&journal=16&info=aims
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