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Hepatotoxic Effect of Aqueous Leaf Extract of Millettia Aboensis on Wistar Rats

Author

Listed:
  • Onyegeme-Okerenta Blessing M.

    (Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, PMB 5323, Port Harcourt, Rivers State, Nigeria)

  • Onyeike Eugene N.

    (Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, PMB 5323, Port Harcourt, Rivers State, Nigeria)

Abstract

The effect of aqueous leaf extract of Millettia aboensis on the liver of Wistar rats was investigated. The experimental animals were divided into six groups based on their body weight. Groups 1 - 5 were administered with 1000, 2000, 3000, 4000 and 5000mg/kg body weight of the extract respectively while the control group was given normal feed and water. The administration of the extract was for 7days and thereafter, the rats were sacrificed and the effects of the plant extract on the liver investigated. Liver function tests and histological examinations of the liver were carried out. Results for liver enzyme assay showed that aspartate aminotransferase (AST) activity significantly increased (p

Suggested Citation

  • Onyegeme-Okerenta Blessing M. & Onyeike Eugene N., 2015. "Hepatotoxic Effect of Aqueous Leaf Extract of Millettia Aboensis on Wistar Rats," Journal of Biotechnology Research, Academic Research Publishing Group, vol. 1(6), pages 26-30, 12-2015.
    • Handle: RePEc:arp:rjbarp:2015:p:26-30
    DOI: arpgweb.com/?ic=journal&journal=16&info=aims
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