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Enhanced recovery after surgery protocol in oesophageal cancer surgery: Systematic review and meta-analysis

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Listed:
  • Magdalena Pisarska
  • Piotr Małczak
  • Piotr Major
  • Michał Wysocki
  • Andrzej Budzyński
  • Michał Pędziwiatr

Abstract

Background: Enhanced Recovery After Surgery (ERAS) protocol are well established in many surgical disciplines, leading to decrease in morbidity and length of hospital stay. These multi-modal protocols have been also introduced to oesophageal cancer surgery. This review aimed to evaluate current literature on ERAS in oesophageal cancer surgery and conduct a meta-analysis on primary and secondary outcomes. Methods: MEDLINE, Embase, Scopus and Cochrane Library were searched for eligible studies. We analyzed data up to May 2016. Eligible studies had to contain four described ERAS protocol elements. The primary outcome was overall morbidity. Secondary outcomes included length of hospital stay, specific complications, mortality and readmissions. Random effect meta-analyses were undertaken. Results: Initial search yielded 1,064 articles. Thorough evaluation resulted in 13 eligible articles which were analyzed. A total of 2,042 patients were included in the analysis (1,058 ERAS group and 984 treated with traditional protocols). Analysis of overall morbidity as well as complication rate did not show any significant reduction. Non-surgical complications and pulmonary complications were significantly lower in the ERAS group, RR = 0.71 95% CI 0.62–0.80, p

Suggested Citation

  • Magdalena Pisarska & Piotr Małczak & Piotr Major & Michał Wysocki & Andrzej Budzyński & Michał Pędziwiatr, 2017. "Enhanced recovery after surgery protocol in oesophageal cancer surgery: Systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0174382
    DOI: 10.1371/journal.pone.0174382
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