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Vitamin D and hypertension: Prospective study and meta-analysis

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  • Dan Qi
  • Xiao-lu Nie
  • Shouling Wu
  • Jun Cai

Abstract

Objectives: The study sought to determine the link between vitamin D concentrations and incident hypertension in prospective study and meta-analysis. Methods: The study was embedded in the Kailuan Study, a population-based cohort of adults that contains underground miners. In 2012, we studied 2,456 men and women free of prevalent hypertension, age 21 to 67 at baseline. Serum 25-hydroxyvitamin D was measured from previously frozen baseline samples using ELISA (Enzyme-Linked ImmunoadSorbent Assay). We use the logistic regression analysis to estimate the odd radio (ORs) 95% confidence intervals (CIs) for 25-hydroxyvitamin D [25(OH)D] concentrations with incident hypertension. To help place our new data in context, we conducted a systemic review and meta-analysis of previous prospective reports of vitamin D and hypertension. Results: During a median follow-up of 2 years, 42.6% of the cohort (n = 1047) developed hypertension. Compared with the 25-hydroxyvitamin D >30ng/ml, 25-hydroxyvitamin D

Suggested Citation

  • Dan Qi & Xiao-lu Nie & Shouling Wu & Jun Cai, 2017. "Vitamin D and hypertension: Prospective study and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0174298
    DOI: 10.1371/journal.pone.0174298
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