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A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic

Author

Listed:
  • Cavin K Ward-Caviness
  • Lucas M Neas
  • Colette Blach
  • Carol S Haynes
  • Karen LaRocque-Abramson
  • Elizabeth Grass
  • Z Elaine Dowdy
  • Robert B Devlin
  • David Diaz-Sanchez
  • Wayne E Cascio
  • Marie Lynn Miranda
  • Simon G Gregory
  • Svati H Shah
  • William E Kraus
  • Elizabeth R Hauser

Abstract

Air pollution is a worldwide contributor to cardiovascular disease mortality and morbidity. Traffic-related air pollution is a widespread environmental exposure and is associated with multiple cardiovascular outcomes such as coronary atherosclerosis, peripheral arterial disease, and myocardial infarction. Despite the recognition of the importance of both genetic and environmental exposures to the pathogenesis of cardiovascular disease, studies of how these two contributors operate jointly are rare. We performed a genome-wide interaction study (GWIS) to examine gene-traffic exposure interactions associated with coronary atherosclerosis. Using race-stratified cohorts of 538 African-Americans (AA) and 1562 European-Americans (EA) from a cardiac catheterization cohort (CATHGEN), we identify gene-by-traffic exposure interactions associated with the number of significantly diseased coronary vessels as a measure of chronic atherosclerosis. We found five suggestive (P

Suggested Citation

  • Cavin K Ward-Caviness & Lucas M Neas & Colette Blach & Carol S Haynes & Karen LaRocque-Abramson & Elizabeth Grass & Z Elaine Dowdy & Robert B Devlin & David Diaz-Sanchez & Wayne E Cascio & Marie Lynn , 2017. "A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-16, March.
    • Handle: RePEc:plo:pone00:0173880
    DOI: 10.1371/journal.pone.0173880
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