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IVGTT-based simple assessment of glucose tolerance in the Zucker fatty rat: Validation against minimal models

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Listed:
  • Micaela Morettini
  • Emanuela Faelli
  • Luisa Perasso
  • Sandro Fioretti
  • Laura Burattini
  • Piero Ruggeri
  • Francesco Di Nardo

Abstract

For the assessment of glucose tolerance from IVGTT data in Zucker rat, minimal model methodology is reliable but time- and money-consuming. This study aimed to validate for the first time in Zucker rat, simple surrogate indexes of insulin sensitivity and secretion against the glucose-minimal-model insulin sensitivity index (SI) and against first- (Φ1) and second-phase (Φ2) β-cell responsiveness indexes provided by C-peptide minimal model. Validation of the surrogate insulin sensitivity index (ISI) and of two sets of coupled insulin-based indexes for insulin secretion, differing from the cut-off point between phases (FPIR3-SPIR3, t = 3 min and FPIR5-SPIR5, t = 5 min), was carried out in a population of ten Zucker fatty rats (ZFR) and ten Zucker lean rats (ZLR). Considering the whole rat population (ZLR+ZFR), ISI showed a significant strong correlation with SI (Spearman’s correlation coefficient, r = 0.88; P

Suggested Citation

  • Micaela Morettini & Emanuela Faelli & Luisa Perasso & Sandro Fioretti & Laura Burattini & Piero Ruggeri & Francesco Di Nardo, 2017. "IVGTT-based simple assessment of glucose tolerance in the Zucker fatty rat: Validation against minimal models," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-17, March.
    • Handle: RePEc:plo:pone00:0173200
    DOI: 10.1371/journal.pone.0173200
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