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Prognostic impact of pretherapeutic gamma-glutamyltransferase on patients with nasopharyngeal carcinoma

Author

Listed:
  • Yue-Feng Wen
  • Xian-Zi Yang
  • Li-Si Zeng
  • Hai-Hua Peng
  • Wen-Jin Huang
  • Long-Mei Cai
  • Tong-Chong Zhou
  • Xiao-Dan Lin

Abstract

Background: Gamma-glutamyltransferase (GGT) is a membrane-bound enzyme involved in the metabolism of glutathione. Studies suggested that GGT played an important role in the tumor development, progression, invasion and drug resistance and prognosis. The association between GGT and prognosis of patients with nasopharyngeal carcinoma (NPC) was unknown. This study was conducted to investigate the association of pretherapeutic serum level of GGT with clinical-pathological parameters and survival in patients with NPC. Methods: Two hundred and twenty-two patients with NPC were recruited in this study and were stratified into two GGT risk groups (≤ 34.5 U/L, > 34.5 U/L). The association of pretherapeutic serum GGT levels with clinical–pathological parameters was examined. Univariate and multivariate survival analyses were performed. Findings: The pretherapeutic serum level of GGT was not associated with gender, age, pathology, T stage, N stage, TNM stage, chemotherapy or radiotherapy in patients with NPC. Patients in the high-risk GGT group had a poorer survival than the low-risk GGT group (3-year overall survival, 74.2% vs. 50.2%, P = 0.001; 3-year progression-free survival, 76.4% vs. 47.1%, P

Suggested Citation

  • Yue-Feng Wen & Xian-Zi Yang & Li-Si Zeng & Hai-Hua Peng & Wen-Jin Huang & Long-Mei Cai & Tong-Chong Zhou & Xiao-Dan Lin, 2017. "Prognostic impact of pretherapeutic gamma-glutamyltransferase on patients with nasopharyngeal carcinoma," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-10, February.
    • Handle: RePEc:plo:pone00:0172345
    DOI: 10.1371/journal.pone.0172345
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