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Effect of Chinese patent medicine Si-Mo-Tang oral liquid for functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials

Author

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  • Yunxia Hu
  • Yu Bai
  • Zhiyun Hua
  • Jie Yang
  • Huahui Yang
  • Wenjun Chen
  • Junwei Xu
  • Zhiqiang Zhao

Abstract

Background: Si-Mo-Tang oral liquid (SMT) has been widely used to treat functional dyspepsia (FD), but the effectiveness is still controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to assess the efficacy and adverse effects of SMT for FD. Methods: Investigators searched for articles with publication dates to June 21, 2016, from 9 English and Chinese electronic databases. Comparisons were SMT alone or SMT in combination with western medicine as experimental intervention, and western medicine or placebo as the control. We used the Cochrane collaboration tool for assessing risk of bias to evaluate methodologies. Data were synthesized with RevMan 5.3 software. (PROSPERO Registration #CRD42016042003) Results: Twenty-seven RCTs were included in the review, involving 2,713 participants: 1,383 subjects were in the experimental group and 1,330 in the control group. SMT showed a significant improvement in clinical efficacy (RR 1.14; 95% CI 1.09, 1.20; P

Suggested Citation

  • Yunxia Hu & Yu Bai & Zhiyun Hua & Jie Yang & Huahui Yang & Wenjun Chen & Junwei Xu & Zhiqiang Zhao, 2017. "Effect of Chinese patent medicine Si-Mo-Tang oral liquid for functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0171878
    DOI: 10.1371/journal.pone.0171878
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