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Prognostic significance of SETBP1 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia, and chronic neutrophilic leukemia: A meta-analysis

Author

Listed:
  • Li-Hong Shou
  • Dan Cao
  • Xiao-Hui Dong
  • Qiu Fang
  • Ying Wu
  • Yan Zhang
  • Ju-Ping Fei
  • Bao-Lian Xu

Abstract

Objectives: This meta-analysis investigates the prognostic effect of SET binding protein 1 (SETBP1) mutations in patients with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), or chronic neutrophilic leukemia (CNL). Methods: Eligible studies from Pubmed, Embase, and Web of Science were searched from database inception through April 2016. Hazard ratios (HRs) and 95% confidence interval (CI) of overall survival (OS) were pooled to calculate the prognostic significance of SETBP1 mutation in patients. Results: A total of 12 studies with 2321 patients were included in this meta-analysis; 4 studies for MDS, 5 studies for CMML, and 3 studies for CNL. Pooled results suggested that MDS and CMML patients with SETBP1 mutations had a significantly poorer prognosis when compared with patients with wild-type SETBP1 (MDS: HR = 1.808, 95% CI (1.218–2.685), P = 0.001; CMML: HR = 2.223, 95% CI (1.493–3.308), P

Suggested Citation

  • Li-Hong Shou & Dan Cao & Xiao-Hui Dong & Qiu Fang & Ying Wu & Yan Zhang & Ju-Ping Fei & Bao-Lian Xu, 2017. "Prognostic significance of SETBP1 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia, and chronic neutrophilic leukemia: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-14, February.
    • Handle: RePEc:plo:pone00:0171608
    DOI: 10.1371/journal.pone.0171608
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