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Multiple strains probiotics appear to be the most effective probiotics in the prevention of necrotizing enterocolitis and mortality: An updated meta-analysis

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  • Hung-Yang Chang
  • Jin-Hua Chen
  • Jui-Hsing Chang
  • Hung-Chih Lin
  • Chien-Yu Lin
  • Chun-Chih Peng

Abstract

Background: Some oral probiotics have been shown to prevent necrotizing enterocolitis (NEC) and decrease mortality effectively in preterm very low birth weight (PVLBW) infants. However, it is unclear whether a single probiotic or a mixture of probiotics is most effective for the prevention of NEC. Objective: A meta-analysis was conducted by reviewing the most up to date literature to investigate whether multiple strains probiotics are more effective than a single strain in reducing NEC and death in PVLBW infants. Data sources: Relevant studies were identified by searches of the MEDLINE, EMBASE, and Cochrane CENTRAL databases, from 2001 to 2016. Data extraction and synthesis: The inclusion criteria were randomized controlled trials of any enteral probiotic supplementation that was initiated within the first 7 days and continued for at least 14 days in preterm infants (≤ 34 weeks’ gestation) and/or those of a birth weight ≤1500 g. Results: A total of 25 trials (n = 7345 infants) were eligible for inclusion in the meta-analysis using a fixed-effects model. Multiple strains probiotics were associated with a marked reduction in the incidence of NEC, with a pooled OR of 0.36 (95% CI, 0.24–0.53; P

Suggested Citation

  • Hung-Yang Chang & Jin-Hua Chen & Jui-Hsing Chang & Hung-Chih Lin & Chien-Yu Lin & Chun-Chih Peng, 2017. "Multiple strains probiotics appear to be the most effective probiotics in the prevention of necrotizing enterocolitis and mortality: An updated meta-analysis," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-14, February.
    • Handle: RePEc:plo:pone00:0171579
    DOI: 10.1371/journal.pone.0171579
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