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Comparison of the population excess fraction of Chlamydia trachomatis infection on pelvic inflammatory disease at 12-months in the presence and absence of chlamydia testing and treatment: Systematic review and retrospective cohort analysis

Author

Listed:
  • Bethan Davies
  • Katy M E Turner
  • Stella Leung
  • B Nancy Yu
  • Maria Frølund
  • Thomas Benfield
  • James Blanchard
  • Henrik Westh
  • on behalf of the Danish Chlamydia Study
  • Helen Ward

Abstract

Background: The impact of Chlamydia trachomatis (chlamydia) control on the incidence of pelvic inflammatory disease (PID) is theoretically limited by the proportion of PID caused by chlamydia. We estimate the population excess fraction (PEF) of treated chlamydia infection on PID at 12-months in settings with widespread chlamydia control (testing and treatment) and compare this to the estimated PEF of untreated chlamydia. Methods: We used two large retrospective population-based cohorts of women of reproductive age from settings with widespread chlamydia control to calculate the PEF of treated chlamydia on PID at 12-months. We undertook a systematic review to identify further studies that reported the risk of PID in women who were tested for chlamydia (infected and uninfected). We used the same method to calculate the PEF in eligible studies then compared all estimates of PEF. Results: The systematic review identified a single study, a randomised controlled trial of chlamydia screening (POPI-RCT). In the presence of testing and treatment

Suggested Citation

  • Bethan Davies & Katy M E Turner & Stella Leung & B Nancy Yu & Maria Frølund & Thomas Benfield & James Blanchard & Henrik Westh & on behalf of the Danish Chlamydia Study & Helen Ward, 2017. "Comparison of the population excess fraction of Chlamydia trachomatis infection on pelvic inflammatory disease at 12-months in the presence and absence of chlamydia testing and treatment: Systematic r," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-12, February.
    • Handle: RePEc:plo:pone00:0171551
    DOI: 10.1371/journal.pone.0171551
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