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Fecal microbiota transplantation in patients with slow-transit constipation: A randomized, clinical trial

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Listed:
  • Hongliang Tian
  • Xiaolong Ge
  • Yongzhan Nie
  • Linfeng Yang
  • Chao Ding
  • Lynne V McFarland
  • Xueying Zhang
  • Qiyi Chen
  • Jianfeng Gong
  • Ning Li

Abstract

Fecal microbiota transplantation has been proposed as a therapeutic approach for chronic constipation. This randomized, controlled trial aimed to compare the effects of conventional treatment alone (control) with additional treatment with FMT (intervention) in patients with slow-transit constipation (STC). Adults with STC were randomized to receive intervention or control treatment. The control group received education, behavioral strategies, and oral laxatives. The intervention group was additionally provided 6 days of FMT. The primary endpoint was the clinical cure rate (proportion of patients achieving a mean of ≥ three complete spontaneous bowel movements [CSBMs] per week]. Secondary outcomes and safety parameters were assessed throughout the study. Sixty patients were randomized to either conventional treatment alone (n = 30) or FMT (n = 30) through a nasointestinal tube. There were significant differences between the intervention group and control group in the clinical improvement rate (intention-to-treat [ITT]: 53.3% vs. 20.0%, P = 0.009), clinical cure rate (ITT: 36.7% vs. 13.3%, P = 0.04), mean number of CSBMs per week (ITT: 3.2 ± 1.4 vs. 2.1 ± 1.2, P = 0.001), and the Wexner constipation score (ITT: 8.6 ± 1.5 vs. 12.7 ± 2.5, P

Suggested Citation

  • Hongliang Tian & Xiaolong Ge & Yongzhan Nie & Linfeng Yang & Chao Ding & Lynne V McFarland & Xueying Zhang & Qiyi Chen & Jianfeng Gong & Ning Li, 2017. "Fecal microbiota transplantation in patients with slow-transit constipation: A randomized, clinical trial," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-10, February.
    • Handle: RePEc:plo:pone00:0171308
    DOI: 10.1371/journal.pone.0171308
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