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Early BCR-ABL1 Transcript Decline after 1 Month of Tyrosine Kinase Inhibitor Therapy as an Indicator for Treatment Response in Chronic Myeloid Leukemia

Author

Listed:
  • Mohamed El Missiry
  • Henrik Hjorth-Hansen
  • Johan Richter
  • Ulla Olson-Strömberg
  • Leif Stenke
  • Kimmo Porkka
  • Anna Kreutzman
  • Satu Mustjoki

Abstract

In chronic myeloid leukemia (CML), early treatment prediction is important to identify patients with inferior overall outcomes. We examined the feasibility of using reductions in BCR-ABL1 transcript levels after 1 month of tyrosine kinase inhibitor (TKI) treatment to predict therapy response. Fifty-two first-line TKI-treated CML patients were included (imatinib n = 26, dasatinib n = 21, nilotinib n = 5), and BCR-ABL1 transcript levels were measured at diagnosis (dg) and 1, 3, 6, 12, 18, 24, and 36 months. The fold change of the BCR-ABL1 transcripts at 1 month compared to initial BCR-ABL1 transcript levels was used to indicate early therapy response. In our cohort, 21% of patients had no decrease in BCR-ABL1 transcript levels after 1 month and were classified as poor responders. Surprisingly, these patients had lower BCR-ABL1 transcript levels at dg compared to responders (31% vs. 48%, p = 0.0083). Poor responders also significantly more often had enlarged spleen (55% vs. 15%; p

Suggested Citation

  • Mohamed El Missiry & Henrik Hjorth-Hansen & Johan Richter & Ulla Olson-Strömberg & Leif Stenke & Kimmo Porkka & Anna Kreutzman & Satu Mustjoki, 2017. "Early BCR-ABL1 Transcript Decline after 1 Month of Tyrosine Kinase Inhibitor Therapy as an Indicator for Treatment Response in Chronic Myeloid Leukemia," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-17, January.
    • Handle: RePEc:plo:pone00:0171041
    DOI: 10.1371/journal.pone.0171041
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