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Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia

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  • Max Winerdal
  • Vijay Urmaliya
  • Malin E Winerdal
  • Bertil B Fredholm
  • Ola Winqvist
  • Ulrika Ådén

Abstract

In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neonatal brain injury.

Suggested Citation

  • Max Winerdal & Vijay Urmaliya & Malin E Winerdal & Bertil B Fredholm & Ola Winqvist & Ulrika Ådén, 2017. "Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0170545
    DOI: 10.1371/journal.pone.0170545
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