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Discontinuation from Antiretroviral Therapy: A Continuing Challenge among Adults in HIV Care in Ethiopia: A Systematic Review and Meta-Analysis

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  • Hailay Abrha Gesesew
  • Paul Ward
  • Kifle Woldemichael Hajito
  • Garumma Tolu Feyissa
  • Leila Mohammadi
  • Lillian Mwanri

Abstract

Background: Discontinuation of antiretroviral therapy (ART) reduces the immunological benefit of treatment and increases complications related to human immune-deficiency virus (HIV). However, the risk factors for ART discontinuation are poorly understood in developing countries particularly in Ethiopia. This review aimed to assess the best available evidence regarding risk factors for ART discontinuation in Ethiopia. Methods: Quantitative studies conducted in Ethiopia between 2002 and 2015 that evaluated factors associated with ART discontinuation were sought across six major databases. Only English language articles were included. This review considered studies that included the following outcome: ART treatment discontinuation, i.e. ‘lost to follow up’, ‘defaulting’ and ‘stopping medication’. Meta- analysis was performed with Mantel Haenszel method using Revman-5 software. Summary statistics were expressed as pooled odds ratio with 95% confidence intervals at a p-value of

Suggested Citation

  • Hailay Abrha Gesesew & Paul Ward & Kifle Woldemichael Hajito & Garumma Tolu Feyissa & Leila Mohammadi & Lillian Mwanri, 2017. "Discontinuation from Antiretroviral Therapy: A Continuing Challenge among Adults in HIV Care in Ethiopia: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-19, January.
    • Handle: RePEc:plo:pone00:0169651
    DOI: 10.1371/journal.pone.0169651
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