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Development and External Validation of the Korean Prostate Cancer Risk Calculator for High-Grade Prostate Cancer: Comparison with Two Western Risk Calculators in an Asian Cohort

Author

Listed:
  • Jae Young Park
  • Sungroh Yoon
  • Man Sik Park
  • Hoon Choi
  • Jae Hyun Bae
  • Du Geon Moon
  • Sung Kyu Hong
  • Sang Eun Lee
  • Chanwang Park
  • Seok-Soo Byun

Abstract

Purpose: We developed the Korean Prostate Cancer Risk Calculator for High-Grade Prostate Cancer (KPCRC-HG) that predicts the probability of prostate cancer (PC) of Gleason score 7 or higher at the initial prostate biopsy in a Korean cohort (http://acl.snu.ac.kr/PCRC/RISC/). In addition, KPCRC-HG was validated and compared with internet-based Western risk calculators in a validation cohort. Materials and Methods: Using a logistic regression model, KPCRC-HG was developed based on the data from 602 previously unscreened Korean men who underwent initial prostate biopsies. Using 2,313 cases in a validation cohort, KPCRC-HG was compared with the European Randomized Study of Screening for PC Risk Calculator for high-grade cancer (ERSPCRC-HG) and the Prostate Cancer Prevention Trial Risk Calculator 2.0 for high-grade cancer (PCPTRC-HG). The predictive accuracy was assessed using the area under the receiver operating characteristic curve (AUC) and calibration plots. Results: PC was detected in 172 (28.6%) men, 120 (19.9%) of whom had PC of Gleason score 7 or higher. Independent predictors included prostate-specific antigen levels, digital rectal examination findings, transrectal ultrasound findings, and prostate volume. The AUC of the KPCRC-HG (0.84) was higher than that of the PCPTRC-HG (0.79, p

Suggested Citation

  • Jae Young Park & Sungroh Yoon & Man Sik Park & Hoon Choi & Jae Hyun Bae & Du Geon Moon & Sung Kyu Hong & Sang Eun Lee & Chanwang Park & Seok-Soo Byun, 2017. "Development and External Validation of the Korean Prostate Cancer Risk Calculator for High-Grade Prostate Cancer: Comparison with Two Western Risk Calculators in an Asian Cohort," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-11, January.
    • Handle: RePEc:plo:pone00:0168917
    DOI: 10.1371/journal.pone.0168917
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