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Impact of Hyperglycemia on Outcomes among Patients Receiving Neoadjuvant Chemotherapy for Bulky Early Stage Cervical Cancer

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  • Jing Li
  • Miao-fang Wu
  • Huai-wu Lu
  • Bing-zhong Zhang
  • Li-juan Wang
  • Zhong-qiu Lin

Abstract

Background: The impact of hyperglycemia on survival of patients undergoing neoadjuvant chemotherapy (NACT) for bulky early stage cervical cancer (BESCC) has not been explored. Method: Records of patients who received NACT and radical hysterectomy in our institution between January 2005 and June 2010 were reviewed. Results: In total, 347 patients were included. The median follow-up time was 37 months (range: 4–65). Patients with hyperglycemia (fasting blood glucose ≥ 100 mg/dl) had shorter recurrence-free survival (RFS) (univariate hazard ratio [HR] = 1.95, 95% confidence interval [CI] [1.16, 3.28], P = 0.010) and cancer-specific survival (CSS) (univariate HR = 2.24, 95% CI [1.33, 3.78], P = 0.002) compared with those with euglycemia (fasting blood glucose

Suggested Citation

  • Jing Li & Miao-fang Wu & Huai-wu Lu & Bing-zhong Zhang & Li-juan Wang & Zhong-qiu Lin, 2016. "Impact of Hyperglycemia on Outcomes among Patients Receiving Neoadjuvant Chemotherapy for Bulky Early Stage Cervical Cancer," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-15, November.
    • Handle: RePEc:plo:pone00:0166612
    DOI: 10.1371/journal.pone.0166612
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