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Prognostic Value of Serum Lactate Dehydrogenase in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

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  • Jie Shen
  • Zhen Chen
  • Qianfeng Zhuang
  • Min Fan
  • Tao Ding
  • Hao Lu
  • Xiaozhou He

Abstract

Background: Recently, many studies have shown that the serum lactate dehydrogenase (LDH) level is related to the prognosis of renal cell carcinoma (RCC). We launched this meta-analysis to assess the prognostic value of serum LDH in patients with RCC. Methods: We searched PubMed, Embase and Web of Science for information on serum LDH and the outcome of RCC through June 14, 2016. The hazard ratio (HR) and its 95% confidence interval (CI) for overall survival (OS) and progression-free survival (PFS) were extracted and integrated from the matching studies. Results: A total of 29 studies including 6629 patients with RCC were incorporated in this meta-analysis. Patients whose serum LDH levels were elevated had a lower OS (HR = 2.13, 95% CI = 1.69–2.69, P

Suggested Citation

  • Jie Shen & Zhen Chen & Qianfeng Zhuang & Min Fan & Tao Ding & Hao Lu & Xiaozhou He, 2016. "Prognostic Value of Serum Lactate Dehydrogenase in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0166482
    DOI: 10.1371/journal.pone.0166482
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