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Outcomes of Adult In-Hospital Cardiac Arrest Treated with Targeted Temperature Management: A Retrospective Cohort Study

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Listed:
  • Chih-Hung Wang
  • Chien-Hua Huang
  • Wei-Tien Chang
  • Min-Shan Tsai
  • Ping-Hsun Yu
  • Yen-Wen Wu
  • Wen-Jone Chen

Abstract

Aim: Targeted temperature management (TTM) for in-hospital cardiac arrest (IHCA) is given different recommendation levels within international resuscitation guidelines. We aimed to identify whether TTM would be associated with favourable outcomes following IHCA and to determine which factors would influence the decision to implement TTM. Methods: We conducted a retrospective observational study in a single medical centre. We included adult patients suffering IHCA between 2006 and 2014. We used multivariable logistic regression analysis to evaluate associations between independent variables and outcomes. Results: We included a total of 678 patients in our analysis; only 22 (3.2%) patients received TTM. Most (81.1%) patients met at least one exclusion criteria for TTM. In all, 144 (21.2%) patients survived to hospital discharge; among them, 60 (8.8%) patients displayed favourable neurological status at discharge. TTM use was significantly associated with favourable neurological outcome (OR: 3.74, 95% confidence interval [CI]: 1.19–11.00; p-value = 0.02), but it was not associated with survival (OR: 1.41, 95% CI: 0.54–3.66; p-value = 0.48). Arrest in the emergency department was positively associated with TTM use (OR: 22.48, 95% CI: 8.40–67.64; p value

Suggested Citation

  • Chih-Hung Wang & Chien-Hua Huang & Wei-Tien Chang & Min-Shan Tsai & Ping-Hsun Yu & Yen-Wen Wu & Wen-Jone Chen, 2016. "Outcomes of Adult In-Hospital Cardiac Arrest Treated with Targeted Temperature Management: A Retrospective Cohort Study," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0166148
    DOI: 10.1371/journal.pone.0166148
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