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Atrial Substrate Modification in Atrial Fibrillation: Targeting GP or CFAE? Evidence from Meta-Analysis of Clinical Trials

Author

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  • Mu Qin
  • Xu Liu
  • Shao-Hui Wu
  • Xiao-Dong Zhang

Abstract

Several clinically relevant outcomes post atrial substrate modification in patients with atrial fibrillation (AF) have not been systematically analyzed among published studies on adjunctive cardiac ganglionated plexi (GP) or complex fractionated atrial electograms (CFAE) ablation vs. pulmonary vein isolation (PVI) alone. Out of 176 reports identified, the present meta-analysis included 14 randomized and non-randomized controlled trials (1613 patients) meeting inclusion criteria. Addition of GP ablation to PVI significantly increased freedom from atrial tachyarrhythmia in short- (OR: 1.72; P = 0.003) and long-term (OR: 2.0, P = 0.0006) follow-up, while adjunctive CFAE ablation did not after one or repeat procedure (P

Suggested Citation

  • Mu Qin & Xu Liu & Shao-Hui Wu & Xiao-Dong Zhang, 2016. "Atrial Substrate Modification in Atrial Fibrillation: Targeting GP or CFAE? Evidence from Meta-Analysis of Clinical Trials," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-15, October.
    • Handle: RePEc:plo:pone00:0164989
    DOI: 10.1371/journal.pone.0164989
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