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Long-Term Outcome of Combined (Percutaneous Intramyocardial and Intracoronary) Application of Autologous Bone Marrow Mononuclear Cells Post Myocardial Infarction: The 5-Year MYSTAR Study

Author

Listed:
  • Mariann Gyöngyösi
  • Georgiana-Aura Giurgea
  • Bonni Syeda
  • Silvia Charwat
  • Beatrice Marzluf
  • Julia Mascherbauer
  • Andras Jakab
  • Abelina Zimba
  • Márta Sárközy
  • Noemi Pavo
  • Heinz Sochor
  • Senta Graf
  • Irene Lang
  • Gerald Maurer
  • Jutta Bergler-Klein
  • on behalf of the MYSTAR investigators

Abstract

Objective: The long-term (5-year) outcome of early (3–6 weeks after acute myocardial infarction [AMI], BM-MNC Early group) and late (3–4 months after AMI, BM-MNC Late group) combined (percutaneous intramyocardial and intracoronary) delivery of autologous bone marrow mononuclear cells (BM-MNCs) was evaluated in patients with ejection fractions (EF) between 30–45% post-AMI. Methods: Major adverse cardiac and cerebrovascular events (MACCE) and hospitalization were recorded. Left (LV) and right (RV) ventricular function were measured by transthoracic echocardiography. Cardiac magnetic resonance imaging (MRI) and myocardial single photon emission computed tomography was performed in a subgroup of patients. Pre-cell therapy myocardial voltage values of treated areas (assessed by NOGA mapping) were correlated with clinical outcome. Results: Five-year MACCE incidences (7.4%. vs 24.1%) and the composite of all adverse events (11.1% vs 27.6%) were not different between the Early and Late treatment groups. The significant LV-EF increase at 1-year follow-up was preserved at the 5-year control (from baseline to 5-year: 5.3%, 95% CI:0.5–10.1, and 5.7%, 95% CI:1.7–9.6, p

Suggested Citation

  • Mariann Gyöngyösi & Georgiana-Aura Giurgea & Bonni Syeda & Silvia Charwat & Beatrice Marzluf & Julia Mascherbauer & Andras Jakab & Abelina Zimba & Márta Sárközy & Noemi Pavo & Heinz Sochor & Senta Gra, 2016. "Long-Term Outcome of Combined (Percutaneous Intramyocardial and Intracoronary) Application of Autologous Bone Marrow Mononuclear Cells Post Myocardial Infarction: The 5-Year MYSTAR Study," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-17, October.
    • Handle: RePEc:plo:pone00:0164908
    DOI: 10.1371/journal.pone.0164908
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