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Development of Novel Methods to Define Deficits in Appendicular Lean Mass Relative to Fat Mass

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  • David Weber
  • Jin Long
  • Mary B Leonard
  • Babette Zemel
  • Joshua F Baker

Abstract

Background: Recent studies suggest that adjustment of measures of lean mass for adiposity improves associations with physical function. Our objective was to develop and test a method to adjust appendicular lean mass for adiposity. Methods: Whole-body DXA data in 14,850 adults in the National Health and Nutrition Examination Survey were used to generate sex-, and race-specific standard deviation scores (Z-Scores relative to age and T-scores relative to 25 year-olds) for appendicular lean mass index (ALMI, kg/m2) and fat mass index (FMI, kg/m2). Correlations between ALMI and FMI Z- and T-Scores were assessed within demographic categories. Fat-adjusted ALMI (ALMIFMI) scores were determined using residual methods. Sarcopenia was defined as a T-Score 0.50; p

Suggested Citation

  • David Weber & Jin Long & Mary B Leonard & Babette Zemel & Joshua F Baker, 2016. "Development of Novel Methods to Define Deficits in Appendicular Lean Mass Relative to Fat Mass," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-16, October.
    • Handle: RePEc:plo:pone00:0164385
    DOI: 10.1371/journal.pone.0164385
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