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Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results

Author

Listed:
  • Pawel Kuklik
  • Benjamin Schäffer
  • Boris A Hoffmann
  • Anand N Ganesan
  • Doreen Schreiber
  • Julia M Moser
  • Ruken Ö Akbulak
  • Arian Sultan
  • Daniel Steven
  • Bart Maesen
  • Ulrich Schotten
  • Christian Meyer
  • Stephan Willems

Abstract

Background: Electrogram-based identification of the regions maintaining persistent Atrial Fibrillation (AF) is a subject of ongoing debate. Here, we explore the concept of local electrical dyssynchrony to identify AF drivers. Methods and Results: Local electrical dyssynchrony was calculated using mean phase coherence. High-density epicardial mapping along with mathematical model were used to explore the link between local dyssynchrony and properties of wave conduction. High-density mapping showed a positive correlation between the dyssynchrony and number of fibrillatory waves (R2 = 0.68, p

Suggested Citation

  • Pawel Kuklik & Benjamin Schäffer & Boris A Hoffmann & Anand N Ganesan & Doreen Schreiber & Julia M Moser & Ruken Ö Akbulak & Arian Sultan & Daniel Steven & Bart Maesen & Ulrich Schotten & Christian Me, 2016. "Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-15, October.
    • Handle: RePEc:plo:pone00:0164236
    DOI: 10.1371/journal.pone.0164236
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