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Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison

Author

Listed:
  • Thierry Poynard
  • Tam Pham
  • Hugo Perazzo
  • Mona Munteanu
  • Elena Luckina
  • Djamel Elaribi
  • Yen Ngo
  • Luminita Bonyhay
  • Noemie Seurat
  • Muriel Legroux
  • An Ngo
  • Olivier Deckmyn
  • Dominique Thabut
  • Vlad Ratziu
  • Olivier Lucidarme
  • FIBROFRANCE-HECAM

Abstract

Background and Aims: Real-time shear wave elastography (2D-SWE) is a two-dimensional transient elastography and a competitor as a biomarker of liver fibrosis in comparison with the standard reference transient elastography by M probe (TE-M). The aims were to compare several criteria of applicability, and to assess inflammation and steatosis impact on elasticity values, two unmet needs. Methods: We took FibroTest as the fibrosis reference and ActiTest and SteatoTest as quantitative estimates of inflammation and steatosis. After standardization of estimates, analyses used curve fitting, quantitative Lin concordance coefficient [LCC], and multivariate logistic regression. Results: A total of 2,251 consecutive patients were included. We validated the predetermined 0.2 kPa cut-off as a too low minimal elasticity value identifying not-reliable 2D-SWE results (LCC with FibroTest = 0.0281[-0.119;0.175]. Other criteria, elasticity CV, body mass index and depth of measures were not sufficiently discriminant. The applicability of 2D-SWE (95%CI) 89.6%(88.2–90.8), was significantly higher than that of TE, 85.6%(84.0–87.0; P

Suggested Citation

  • Thierry Poynard & Tam Pham & Hugo Perazzo & Mona Munteanu & Elena Luckina & Djamel Elaribi & Yen Ngo & Luminita Bonyhay & Noemie Seurat & Muriel Legroux & An Ngo & Olivier Deckmyn & Dominique Thabut &, 2016. "Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-16, October.
    • Handle: RePEc:plo:pone00:0163276
    DOI: 10.1371/journal.pone.0163276
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