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Antiviral Treatment of HCV-Infected Patients with B-Cell Non-Hodgkin Lymphoma: ANRS HC-13 Lympho-C Study

Author

Listed:
  • Laurent Alric
  • Caroline Besson
  • Nathanael Lapidus
  • Juliette Jeannel
  • Jean-Marie Michot
  • Patrice Cacoub
  • Danielle Canioni
  • Stanislas Pol
  • Frédéric Davi
  • Pascaline Rabiega
  • Loic Ysebaert
  • Delphine Bonnet
  • Olivier Hermine

Abstract

Hepatitis C virus (HCV) infection is associated with lymphoproliferative disorders and B-cell non-Hodgkin lymphomas (B-NHLs). Evaluation of the efficacy and safety profiles of different antiviral therapies in HCV patients with B-NHL is warranted. Methods: First, we evaluated the sustained virologic response (SVR) and safety of Peg-interferon-alpha (Peg-IFN) + ribavirin +/- first protease inhibitors (PI1s) therapy in 61 HCV patients with B-NHL enrolled in a nationwide observational survey compared with 94 matched HCV-infected controls without B-NHL. In a second series, interferon-free regimens using a newly optimal combination therapy with direct-acting antiviral drugs (DAAs) were evaluated in 10 patients with HCV and B-NHL. Results: The main lymphoma type was diffuse large B-cell lymphoma (38%) followed by marginal zone lymphoma (31%). In the multivariate analysis, patients with B-NHL treated by Peg-IFN-based therapy exhibited a greater SVR rate compared with controls, 50.8% vs 30.8%, respectively, p

Suggested Citation

  • Laurent Alric & Caroline Besson & Nathanael Lapidus & Juliette Jeannel & Jean-Marie Michot & Patrice Cacoub & Danielle Canioni & Stanislas Pol & Frédéric Davi & Pascaline Rabiega & Loic Ysebaert & Del, 2016. "Antiviral Treatment of HCV-Infected Patients with B-Cell Non-Hodgkin Lymphoma: ANRS HC-13 Lympho-C Study," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-16, October.
    • Handle: RePEc:plo:pone00:0162965
    DOI: 10.1371/journal.pone.0162965
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