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Depressive Symptoms Correlate with Disability and Disease Course in Multiple Sclerosis Patients: An Italian Multi-Center Study Using the Beck Depression Inventory

Author

Listed:
  • C Solaro
  • E Trabucco
  • A Signori
  • V Martinelli
  • M Radaelli
  • D Centonze
  • S Rossi
  • M G Grasso
  • A Clemenzi
  • S Bonavita
  • A D’Ambrosio
  • F Patti
  • E D’Amico
  • G Cruccu
  • A Truini

Abstract

Background: Depression occurs in about 50% of patients with multiple sclerosis. The aims of this study was to investigate the prevalence of depressive symptoms in a multicenter MS population using the Beck Depression Inventory II (BDI II) and to identify possible correlations between the BDI II score and demographic and clinical variables. Methods: Data were collected in a multi-center, cross-sectional study over a period of six months in six MS centers in Italy using BDI II. Results: 1,011 MS patients participated in the study. 676 subjects were female, with a mean age of 34 years (SD 10.8), mean EDSS of 3.3 (0–8.5) and mean disease duration of 10.3 years (range 1–50 years). 668 (%) subjects scored lower than 14 on the BDI II and 343 (33.9%) scored greater than 14 (14 cut-off score). For patients with BDI>14 multivariate analysis showed a significant difference between EDSS and disease course. BDI II scores for subjects with secondary progressive (SP) MS were significantly different from primary progressive (PP) patients (p

Suggested Citation

  • C Solaro & E Trabucco & A Signori & V Martinelli & M Radaelli & D Centonze & S Rossi & M G Grasso & A Clemenzi & S Bonavita & A D’Ambrosio & F Patti & E D’Amico & G Cruccu & A Truini, 2016. "Depressive Symptoms Correlate with Disability and Disease Course in Multiple Sclerosis Patients: An Italian Multi-Center Study Using the Beck Depression Inventory," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-9, September.
    • Handle: RePEc:plo:pone00:0160261
    DOI: 10.1371/journal.pone.0160261
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