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Baseline MxA mRNA Expression Predicts Interferon Beta Response in Multiple Sclerosis Patients

Author

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  • Elisabet Matas
  • Laura Bau
  • María Martínez-Iniesta
  • Lucía Romero-Pinel
  • M Alba Mañé
  • Álvaro Cobo-Calvo
  • Sergio Martínez-Yélamos

Abstract

Background: Myxovirus resistance protein A (MxA) is a molecule induced after interferon-beta injection, mostly used to evaluate its bioactivity. There is little available data on clinical utility of baseline MxA mRNA status. The objective of the study is to investigate whether baseline MxA mRNA expression can predict relapse and disease progression in multiple sclerosis patients treated with interferon-beta. Methods: Baseline blood samples were obtained before the first interferon-beta dose was administered to evaluate MxA mRNA expression using real-time polymerase chain reaction (PCR). Demographic and clinical variables were prospectively recorded to define treatment responder and non responder groups. Results: 104 patients were included in the study. Baseline MxA mRNA expression was significantly lower in the group of patients who met the definition of responders (1.07 vs 1.95, Student t test, p

Suggested Citation

  • Elisabet Matas & Laura Bau & María Martínez-Iniesta & Lucía Romero-Pinel & M Alba Mañé & Álvaro Cobo-Calvo & Sergio Martínez-Yélamos, 2014. "Baseline MxA mRNA Expression Predicts Interferon Beta Response in Multiple Sclerosis Patients," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-6, November.
    • Handle: RePEc:plo:pone00:0112758
    DOI: 10.1371/journal.pone.0112758
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    Cited by:

    1. Jana Libertinova & Eva Meluzinova & Ales Tomek & Dana Horakova & Ivana Kovarova & Vaclav Matoska & Simona Kumstyrova & Miroslav Zajac & Eva Hyncicova & Petra Liskova & Eva Houzvickova & Lukas Martinko, 2017. "Myxovirus Resistance Protein A mRNA Expression Kinetics in Multiple Sclerosis Patients Treated with IFNβ," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-12, January.

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