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A Meta-Analysis of Parental Smoking and the Risk of Childhood Brain Tumors

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  • Yi Huang
  • Jianrong Huang
  • Huan Lan
  • GuanYan Zhao
  • ChunZhen Huang

Abstract

Objective: Previous studies regarding the association between parental smoking and the risk of childhood brain tumors (CBT) have reported inconsistent results. We performed a meta-analysis to summarize evidence on this association and to quantify the potential dose-response relationship. Methods: A systematic literature search was conducted in the Medline and Embase databases. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated. Dose–response meta-analysis was also performed for studies that reported categorical risk estimates for a series of smoking exposure levels. Results: A total of 17 studies fulfilled the inclusion criteria. In the meta-analyses, the summary RRs (95% CIs) of CBT for maternal smoking during pregnancy, paternal smoking during pregnancy, maternal smoking before pregnancy, and paternal smoking before pregnancy were 0.96 (0.86–1.07), 1.09 (0.97–1.22), 0.93 (0.85–1.00), and 1.09 (1.00–1.20), respectively. Dose-response meta-analysis also showed no significant association between parental smoking and the risk of CBT. Conclusions: Findings from our meta-analysis indicate that parental smoking may not be associated with a risk of CBT.

Suggested Citation

  • Yi Huang & Jianrong Huang & Huan Lan & GuanYan Zhao & ChunZhen Huang, 2014. "A Meta-Analysis of Parental Smoking and the Risk of Childhood Brain Tumors," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0102910
    DOI: 10.1371/journal.pone.0102910
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    Cited by:

    1. Isabell Katharina Rumrich & Matti Viluksela & Kirsi Vähäkangas & Mika Gissler & Heljä-Marja Surcel & Otto Hänninen, 2016. "Maternal Smoking and the Risk of Cancer in Early Life – A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-23, November.

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