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Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy

Author

Listed:
  • H. Diego Folco

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Venkata R. Chalamcharla

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Tomoyasu Sugiyama

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Gobi Thillainadesan

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Martin Zofall

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Vanivilasini Balachandran

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Jothy Dhakshnamoorthy

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

  • Takeshi Mizuguchi

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
    †Present address: Department of Human Genetics, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa-ku, Yokohama 236-0004, Japan.)

  • Shiv I. S. Grewal

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health)

Abstract

Uniparental disomy in fission yeast is triggered by aberrant expression of gametogenic genes in vegetative cells, and is associated with the activation of meiotic cohesin Rec8 in cells with defects in the RNA interference machinery.

Suggested Citation

  • H. Diego Folco & Venkata R. Chalamcharla & Tomoyasu Sugiyama & Gobi Thillainadesan & Martin Zofall & Vanivilasini Balachandran & Jothy Dhakshnamoorthy & Takeshi Mizuguchi & Shiv I. S. Grewal, 2017. "Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy," Nature, Nature, vol. 543(7643), pages 126-130, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7643:d:10.1038_nature21372
    DOI: 10.1038/nature21372
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