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Editing and methylation at a single site by functionally interdependent activities

Author

Listed:
  • Mary Anne T. Rubio

    (Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University)

  • Kirk W. Gaston

    (Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University
    Rieveschl Laboratories for Mass Spectrometry, University of Cincinnati)

  • Katherine M. McKenney

    (Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University)

  • Ian M. C. Fleming

    (Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University)

  • Zdeněk Paris

    (Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University
    Institute of Parasitology, Biology Centre and Faculty of Sciences, University of South Bohemia)

  • Patrick A. Limbach

    (Rieveschl Laboratories for Mass Spectrometry, University of Cincinnati)

  • Juan D. Alfonzo

    (Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University)

Abstract

The C-to-U deamination at position 32 of tRNAThr in Trypanosoma brucei requires two enzymatic activities and proceeds via formation of a 3-methylcytosine intermediate, supporting the notion of a coupled modification system.

Suggested Citation

  • Mary Anne T. Rubio & Kirk W. Gaston & Katherine M. McKenney & Ian M. C. Fleming & Zdeněk Paris & Patrick A. Limbach & Juan D. Alfonzo, 2017. "Editing and methylation at a single site by functionally interdependent activities," Nature, Nature, vol. 542(7642), pages 494-497, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7642:d:10.1038_nature21396
    DOI: 10.1038/nature21396
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