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Unique human immune signature of Ebola virus disease in Guinea

Author

Listed:
  • Paula Ruibal

    (Heinrich Pette Institute, Leibniz Institute for Experimental Virology
    Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Lisa Oestereich

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Anja Lüdtke

    (Heinrich Pette Institute, Leibniz Institute for Experimental Virology
    Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Beate Becker-Ziaja

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • David M. Wozniak

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Romy Kerber

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Miša Korva

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana)

  • Mar Cabeza-Cabrerizo

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Joseph A. Bore

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Fara Raymond Koundouno

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Sophie Duraffour

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Romy Weller

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Institute of Experimental Virology, Twincore, Center for Experimental and Clinical Infection Research)

  • Anja Thorenz

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Hannover Medical School)

  • Eleonora Cimini

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    National Institute for Infectious Diseases ‘Lazzaro Spallanzani’)

  • Domenico Viola

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    National Institute for Infectious Diseases ‘Lazzaro Spallanzani’)

  • Chiara Agrati

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    National Institute for Infectious Diseases ‘Lazzaro Spallanzani’)

  • Johanna Repits

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Babak Afrough

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Public Health England)

  • Lauren A. Cowley

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Public Health England)

  • Didier Ngabo

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Public Health England)

  • Julia Hinzmann

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Robert Koch Institute)

  • Marc Mertens

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Friedrich Loeffler Institute)

  • Inês Vitoriano

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Public Health England)

  • Christopher H. Logue

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Public Health England)

  • Jan Peter Boettcher

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Robert Koch Institute)

  • Elisa Pallasch

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Andreas Sachse

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Robert Koch Institute)

  • Amadou Bah

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Swiss Tropical and Public Health Institute)

  • Katja Nitzsche

    (German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Eeva Kuisma

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Public Health England)

  • Janine Michel

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Robert Koch Institute)

  • Tobias Holm

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Elsa-Gayle Zekeng

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Isabel García-Dorival

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Institute of Infection and Global Health, University of Liverpool)

  • Roman Wölfel

    (German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Bundeswehr Institute of Microbiology)

  • Kilian Stoecker

    (German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Bundeswehr Institute of Microbiology)

  • Erna Fleischmann

    (German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Bundeswehr Institute of Microbiology)

  • Thomas Strecker

    (German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Institute of Virology, Philipps University)

  • Antonino Di Caro

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    National Institute for Infectious Diseases ‘Lazzaro Spallanzani’)

  • Tatjana Avšič-Županc

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana)

  • Andreas Kurth

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Robert Koch Institute)

  • Silvia Meschi

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    National Institute for Infectious Diseases ‘Lazzaro Spallanzani’)

  • Stephane Mély

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Laboratoire P4-Jean Mérieux, US003 INSERM)

  • Edmund Newman

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Public Health England)

  • Anne Bocquin

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Laboratoire P4-Jean Mérieux, US003 INSERM)

  • Zoltan Kis

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    National Center for Epidemiology, Hungarian National Biosafety Laboratory
    European Centre for Disease Prevention and Control)

  • Anne Kelterbaum

    (German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Institute of Virology, Philipps University)

  • Peter Molkenthin

    (German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Bundeswehr Institute of Microbiology)

  • Fabrizio Carletti

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    National Institute for Infectious Diseases ‘Lazzaro Spallanzani’)

  • Jasmine Portmann

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Federal Office for Civil Protection)

  • Svenja Wolff

    (German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Institute of Virology, Philipps University)

  • Concetta Castilletti

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    National Institute for Infectious Diseases ‘Lazzaro Spallanzani’)

  • Gordian Schudt

    (German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Institute of Virology, Philipps University)

  • Alexandra Fizet

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Unité de Biologie des Infections Virales Emergentes, Institut Pasteur)

  • Lisa J. Ottowell

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Public Health England)

  • Eva Herker

    (Heinrich Pette Institute, Leibniz Institute for Experimental Virology)

  • Thomas Jacobs

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research)

  • Birte Kretschmer

    (Eurice, European Research and Project Office)

  • Ettore Severi

    (European Centre for Disease Prevention and Control)

  • Nobila Ouedraogo

    (Robert Koch Institute)

  • Mar Lago

    (Infectious Diseases Unit, Internal Medicine Service, Hospital La Paz)

  • Anabel Negredo

    (National Center of Microbiology, Institute of Health ‘Carlos III’)

  • Leticia Franco

    (National Center of Microbiology, Institute of Health ‘Carlos III’)

  • Pedro Anda

    (National Center of Microbiology, Institute of Health ‘Carlos III’)

  • Stefan Schmiedel

    (University Medical Center Hamburg-Eppendorf)

  • Benno Kreuels

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    University Medical Center Hamburg-Eppendorf)

  • Dominic Wichmann

    (German Center for Infection Research (DZIF)
    University Medical Center Hamburg-Eppendorf)

  • Marylyn M. Addo

    (German Center for Infection Research (DZIF)
    University Medical Center Hamburg-Eppendorf)

  • Ansgar W. Lohse

    (German Center for Infection Research (DZIF)
    University Medical Center Hamburg-Eppendorf)

  • Hilde De Clerck

    (Médecins sans Frontières)

  • Carolina Nanclares

    (Médecins sans Frontières)

  • Sylvie Jonckheere

    (Médecins sans Frontières)

  • Michel Van Herp

    (Médecins sans Frontières)

  • Armand Sprecher

    (Médecins sans Frontières)

  • Gao Xiaojiang

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research
    Ragon Institute of MGH, MIT and Harvard)

  • Mary Carrington

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research
    Ragon Institute of MGH, MIT and Harvard)

  • Osvaldo Miranda

    (Hospital Militar Central Dr. Carlos J. Finlay)

  • Carlos M. Castro

    (Hospital Militar Central Dr. Carlos J. Finlay)

  • Martin Gabriel

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • Patrick Drury

    (World Health Organization)

  • Pierre Formenty

    (World Health Organization)

  • Boubacar Diallo

    (World Health Organization)

  • Lamine Koivogui

    (Institut National de Santé Publique)

  • N’Faly Magassouba

    (Université Gamal Abdel Nasser de Conakry)

  • Miles W. Carroll

    (European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine
    Public Health England)

  • Stephan Günther

    (Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

  • César Muñoz-Fontela

    (Heinrich Pette Institute, Leibniz Institute for Experimental Virology
    Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research
    German Center for Infection Research (DZIF)
    European Mobile Laboratory Consortium, Bernhard-Nocht-Institute for Tropical Medicine)

Abstract

Fatal Ebola virus disease is characterized by a high proportion of CD4+ and CD8+ T cells expressing the inhibitory molecules CTLA-4 and PD-1, correlating with high virus load; individuals who survive the infection exhibit lower expression of these inhibitory molecules and generate Ebola-specific CD8+ T cells, suggesting that dysregulation of the T cell response is a key component of Ebola virus disease pathophysiology.

Suggested Citation

  • Paula Ruibal & Lisa Oestereich & Anja Lüdtke & Beate Becker-Ziaja & David M. Wozniak & Romy Kerber & Miša Korva & Mar Cabeza-Cabrerizo & Joseph A. Bore & Fara Raymond Koundouno & Sophie Duraffour & Ro, 2016. "Unique human immune signature of Ebola virus disease in Guinea," Nature, Nature, vol. 533(7601), pages 100-104, May.
    • Handle: RePEc:nat:nature:v:533:y:2016:i:7601:d:10.1038_nature17949
    DOI: 10.1038/nature17949
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