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Intracellular pattern recognition receptors in the host response

Author

Listed:
  • Etienne Meylan

    (University of Lausanne)

  • Jürg Tschopp

    (University of Lausanne)

  • Michael Karin

    (University of California at San Diego)

Abstract

The innate immune system relies on its capacity to rapidly detect invading pathogenic microbes as foreign and eliminate them. Indeed, Toll-like receptors are a class of membrane receptors that sense extracellular microbes and trigger anti-pathogen signalling cascades. Recently, intracellular microbial sensors have also been identified, including NOD-like receptors and the helicase-domain-containing antiviral proteins RIG-I and MDA5. Some of these cytoplasmic molecules sense microbial, as well as non-microbial, danger signals, but the mechanisms of recognition used by these sensors remain poorly understood. Nonetheless, it is apparent that these proteins are likely to have critical roles in health and disease.

Suggested Citation

  • Etienne Meylan & Jürg Tschopp & Michael Karin, 2006. "Intracellular pattern recognition receptors in the host response," Nature, Nature, vol. 442(7098), pages 39-44, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7098:d:10.1038_nature04946
    DOI: 10.1038/nature04946
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    Cited by:

    1. Jitendra Maharana & Sukanta Kumar Pradhan & Sachinandan De, 2017. "NOD1CARD Might Be Using Multiple Interfaces for RIP2-Mediated CARD-CARD Interaction: Insights from Molecular Dynamics Simulation," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-20, January.

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