IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_s41467-017-02329-y.html
   My bibliography  Save this article

The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy

Author

Listed:
  • Dan A. Landau

    (New York Genome Center
    Broad Institute
    Weill Cornell Medicine)

  • Clare Sun

    (National Institutes of Health)

  • Daniel Rosebrock

    (Broad Institute)

  • Sarah E. M. Herman

    (National Institutes of Health)

  • Joshua Fein

    (New York Genome Center
    Weill Cornell Medicine
    Tel Aviv University)

  • Mariela Sivina

    (The University of Texas MD Anderson Cancer Center)

  • Chingiz Underbayev

    (National Institutes of Health)

  • Delong Liu

    (National Institutes of Health)

  • Julia Hoellenriegel

    (The University of Texas MD Anderson Cancer Center)

  • Sarangan Ravichandran

    (Leidos Biomedical Research Inc)

  • Mohammed Z. H. Farooqui

    (National Institutes of Health)

  • Wandi Zhang

    (Dana-Farber Cancer Institute)

  • Carrie Cibulskis

    (Broad Institute)

  • Asaf Zviran

    (New York Genome Center
    Weill Cornell Medicine)

  • Donna S. Neuberg

    (Dana-Farber Cancer Institute)

  • Dimitri Livitz

    (Broad Institute)

  • Ivana Bozic

    (University of Washington)

  • Ignaty Leshchiner

    (Broad Institute)

  • Gad Getz

    (Broad Institute)

  • Jan A. Burger

    (The University of Texas MD Anderson Cancer Center)

  • Adrian Wiestner

    (National Institutes of Health)

  • Catherine J. Wu

    (Broad Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

Abstract

Treatment of chronic lymphocytic leukemia (CLL) has shifted from chemo-immunotherapy to targeted agents. To define the evolutionary dynamics induced by targeted therapy in CLL, we perform serial exome and transcriptome sequencing for 61 ibrutinib-treated CLLs. Here, we report clonal shifts (change >0.1 in clonal cancer cell fraction, Q

Suggested Citation

  • Dan A. Landau & Clare Sun & Daniel Rosebrock & Sarah E. M. Herman & Joshua Fein & Mariela Sivina & Chingiz Underbayev & Delong Liu & Julia Hoellenriegel & Sarangan Ravichandran & Mohammed Z. H. Farooq, 2017. "The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02329-y
    DOI: 10.1038/s41467-017-02329-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-02329-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-02329-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02329-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.