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Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses

Author

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  • Minh-Thu Nguyen

    (University of Tübingen
    Hanoi University of Science and Technology)

  • Julia Uebele

    (Federal Regulatory Agency for Vaccines and Biomedicines)

  • Nimerta Kumari

    (University of Tübingen)

  • Hiroshi Nakayama

    (RIKEN Center for Sustainable Resource Science)

  • Lena Peter

    (Federal Regulatory Agency for Vaccines and Biomedicines)

  • Olga Ticha

    (Federal Regulatory Agency for Vaccines and Biomedicines)

  • Anne-Kathrin Woischnig

    (University Hospital Basel)

  • Mathias Schmaler

    (University Hospital Basel)

  • Nina Khanna

    (University Hospital Basel)

  • Naoshi Dohmae

    (RIKEN Center for Sustainable Resource Science)

  • Bok Luel Lee

    (Pusan National University)

  • Isabelle Bekeredjian-Ding

    (Federal Regulatory Agency for Vaccines and Biomedicines)

  • Friedrich Götz

    (University of Tübingen)

Abstract

Lipoproteins (Lpp) of Gram-positive bacteria are major players in alerting our immune system. Here, we show that the TLR2 response induced by commensal species Staphylococcus aureus and Staphylococcus epidermidis is almost ten times lower than that induced by noncommensal Staphylococcus carnosus, and this is at least partially due to their different modifications of the Lpp lipid moieties. The N terminus of the lipid moiety is acylated with a long-chain fatty acid (C17) in S. aureus and S. epidermidis, while it is acylated with a short-chain fatty acid (C2) in S. carnosus. The long-chain N-acylated Lpp, recognized by TLR2–TLR1 receptors, silences innate and adaptive immune responses, while the short-chain N-acetylated Lpp, recognized by TLR2–TLR6 receptors, boosts it.

Suggested Citation

  • Minh-Thu Nguyen & Julia Uebele & Nimerta Kumari & Hiroshi Nakayama & Lena Peter & Olga Ticha & Anne-Kathrin Woischnig & Mathias Schmaler & Nina Khanna & Naoshi Dohmae & Bok Luel Lee & Isabelle Bekered, 2017. "Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02234-4
    DOI: 10.1038/s41467-017-02234-4
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