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Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus

Author

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  • Terkild Brink Buus

    (University of Copenhagen)

  • Niels Ødum

    (University of Copenhagen)

  • Carsten Geisler

    (University of Copenhagen)

  • Jens Peter Holst Lauritsen

    (University of Copenhagen)

Abstract

Murine γδ T cells include subsets that are programmed for distinct effector functions during their development in the thymus. Under pathological conditions, different γδ T cell subsets can be protective or can exacerbate a disease. Here we show that CD117, CD200 and CD371, together with other markers, identify seven developmental stages of γδ T cells. These seven stages can be divided into three distinct developmental pathways that are enriched for different TCRδ repertoires and exhibit characteristic expression patterns associated with adaptive (γδTn), IFN-γ-producing (γδT1) and IFN-γ/IL-4-co-producing γδ T cells (γδNKT). Developmental progression towards both IFN-γ-producing subsets can be induced by TCR signalling, and each pathway results in thymic emigration at a different stage. Finally, we show that γδT1 cells are the predominating IFN-γ-producing subset developing in the adult thymus. Thus, this study maps out three distinct development pathways that result in the programming of γδTn, γδT1 and γδNKT cells.

Suggested Citation

  • Terkild Brink Buus & Niels Ødum & Carsten Geisler & Jens Peter Holst Lauritsen, 2017. "Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01963-w
    DOI: 10.1038/s41467-017-01963-w
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