IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_s41467-017-01913-6.html
   My bibliography  Save this article

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure

Author

Listed:
  • Hélène Choquet

    (Kaiser Permanente Northern California (KPNC), Division of Research)

  • Khanh K. Thai

    (Kaiser Permanente Northern California (KPNC), Division of Research)

  • Jie Yin

    (Kaiser Permanente Northern California (KPNC), Division of Research)

  • Thomas J. Hoffmann

    (Institute for Human Genetics, University of California San Francisco (UCSF)
    Department of Epidemiology and Biostatistics, UCSF)

  • Mark N. Kvale

    (Institute for Human Genetics, University of California San Francisco (UCSF))

  • Yambazi Banda

    (Institute for Human Genetics, University of California San Francisco (UCSF))

  • Catherine Schaefer

    (Kaiser Permanente Northern California (KPNC), Division of Research)

  • Neil Risch

    (Kaiser Permanente Northern California (KPNC), Division of Research
    Institute for Human Genetics, University of California San Francisco (UCSF)
    Department of Epidemiology and Biostatistics, UCSF)

  • K. Saidas Nair

    (Departments of Ophthalmology and Anatomy, School of Medicine, UCSF)

  • Ronald Melles

    (KPNC, Department of Ophthalmology)

  • Eric Jorgenson

    (Kaiser Permanente Northern California (KPNC), Division of Research)

Abstract

Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability. Here, we conduct a genome-wide association study of IOP in 69,756 untreated individuals of European, Latino, Asian, and African ancestry. Multiple longitudinal IOP measurements were collected through electronic health records and, in total, 356,987 measurements were included. We identify 47 genome-wide significant IOP-associated loci (P

Suggested Citation

  • Hélène Choquet & Khanh K. Thai & Jie Yin & Thomas J. Hoffmann & Mark N. Kvale & Yambazi Banda & Catherine Schaefer & Neil Risch & K. Saidas Nair & Ronald Melles & Eric Jorgenson, 2017. "A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01913-6
    DOI: 10.1038/s41467-017-01913-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-01913-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-01913-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01913-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.