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Inverted activity patterns in ventromedial prefrontal cortex during value-guided decision-making in a less-is-more task

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Listed:
  • Georgios K. Papageorgiou

    (Department of Experimental Psychology, University of Oxford
    Massachusetts Institute of Technology)

  • Jerome Sallet

    (Department of Experimental Psychology, University of Oxford)

  • Marco K. Wittmann

    (Department of Experimental Psychology, University of Oxford)

  • Bolton K. H. Chau

    (Department of Experimental Psychology, University of Oxford
    The Hong Kong Polytechnic University)

  • Urs Schüffelgen

    (Department of Experimental Psychology, University of Oxford)

  • Mark J. Buckley

    (Department of Experimental Psychology, University of Oxford)

  • Matthew F. S. Rushworth

    (Department of Experimental Psychology, University of Oxford)

Abstract

Ventromedial prefrontal cortex has been linked to choice evaluation and decision-making in humans but understanding the role it plays is complicated by the fact that little is known about the corresponding area of the macaque brain. We recorded activity in macaques using functional magnetic resonance imaging during two very different value-guided decision-making tasks. In both cases ventromedial prefrontal cortex activity reflected subjective choice values during decision-making just as in humans but the relationship between the blood oxygen level-dependent signal and both decision-making and choice value was inverted and opposite to the relationship seen in humans. In order to test whether the ventromedial prefrontal cortex activity related to choice values is important for decision-making we conducted an additional lesion experiment; lesions that included the same ventromedial prefrontal cortex region disrupted normal subjective evaluation of choices during decision-making.

Suggested Citation

  • Georgios K. Papageorgiou & Jerome Sallet & Marco K. Wittmann & Bolton K. H. Chau & Urs Schüffelgen & Mark J. Buckley & Matthew F. S. Rushworth, 2017. "Inverted activity patterns in ventromedial prefrontal cortex during value-guided decision-making in a less-is-more task," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01833-5
    DOI: 10.1038/s41467-017-01833-5
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