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Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy

Author

Listed:
  • Ingo Marenholz

    (Max-Delbrück-Center (MDC) for Molecular Medicine
    Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center)

  • Sarah Grosche

    (Max-Delbrück-Center (MDC) for Molecular Medicine
    Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center)

  • Birgit Kalb

    (Max-Delbrück-Center (MDC) for Molecular Medicine
    Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center
    Charité University Medical Center)

  • Franz Rüschendorf

    (Max-Delbrück-Center (MDC) for Molecular Medicine)

  • Katharina Blümchen

    (Pulmonology and Cystic Fibrosis, Children’s Hospital, Goethe University)

  • Rupert Schlags

    (Wangen Hospital)

  • Neda Harandi

    (Wangen Hospital)

  • Mareike Price

    (Allergology and Neonatology, Hannover Medical School)

  • Gesine Hansen

    (Allergology and Neonatology, Hannover Medical School)

  • Jürgen Seidenberg

    (Neonatology and Intensive Care, Medical Campus of University Oldenburg)

  • Holger Röblitz

    (Sana Klinikum Lichtenberg)

  • Songül Yürek

    (Charité University Medical Center)

  • Sebastian Tschirner

    (Charité University Medical Center)

  • Xiumei Hong

    (Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health)

  • Xiaobin Wang

    (Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health)

  • Georg Homuth

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald)

  • Carsten O. Schmidt

    (Institute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald)

  • Markus M. Nöthen

    (Life & Brain Center, University of Bonn)

  • Norbert Hübner

    (Max-Delbrück-Center (MDC) for Molecular Medicine)

  • Bodo Niggemann

    (Charité University Medical Center)

  • Kirsten Beyer

    (Charité University Medical Center)

  • Young-Ae Lee

    (Max-Delbrück-Center (MDC) for Molecular Medicine
    Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center)

Abstract

Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food challenge in 497 cases and 2387 controls. We identify five loci at genome-wide significance, the clade B serpin (SERPINB) gene cluster at 18q21.3, the cytokine gene cluster at 5q31.1, the filaggrin gene, the C11orf30/LRRC32 locus, and the human leukocyte antigen (HLA) region. Stratifying the results for the causative food demonstrates that association of the HLA locus is peanut allergy-specific whereas the other four loci increase the risk for any food allergy. Variants in the SERPINB gene cluster are associated with SERPINB10 expression in leukocytes. Moreover, SERPINB genes are highly expressed in the esophagus. All identified loci are involved in immunological regulation or epithelial barrier function, emphasizing the role of both mechanisms in food allergy.

Suggested Citation

  • Ingo Marenholz & Sarah Grosche & Birgit Kalb & Franz Rüschendorf & Katharina Blümchen & Rupert Schlags & Neda Harandi & Mareike Price & Gesine Hansen & Jürgen Seidenberg & Holger Röblitz & Songül Yüre, 2017. "Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01220-0
    DOI: 10.1038/s41467-017-01220-0
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