IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_s41467-017-01120-3.html
   My bibliography  Save this article

Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development

Author

Listed:
  • Pedro Vallecillo-García

    (Freie Universität Berlin
    Max Planck Institute for Molecular Genetics)

  • Mickael Orgeur

    (Freie Universität Berlin
    Max Planck Institute for Molecular Genetics
    Sorbonne Universités, UPMC Univ Paris 06, CNRS UMR7622, IBPS-Developmental Biology Laboratory
    Inserm U1156, IBPS-Developmental Biology Laboratory)

  • Sophie vom Hofe-Schneider

    (Freie Universität Berlin)

  • Jürgen Stumm

    (Freie Universität Berlin
    Max Planck Institute for Molecular Genetics)

  • Verena Kappert

    (Freie Universität Berlin
    Max Planck Institute for Molecular Genetics)

  • Daniel M. Ibrahim

    (Max Planck Institute for Molecular Genetics)

  • Stefan T. Börno

    (Max Planck Institute for Molecular Genetics)

  • Shinichiro Hayashi

    (Inserm, IMRB U955-E10
    Université Paris Est, Faculté de médecine, Créteil, & Ecole Nationale Vétérinaire d’Alfort)

  • Frédéric Relaix

    (Inserm, IMRB U955-E10
    Université Paris Est, Faculté de médecine, Créteil, & Ecole Nationale Vétérinaire d’Alfort)

  • Katrin Hildebrandt

    (University of Cologne)

  • Gerhard Sengle

    (University of Cologne)

  • Manuel Koch

    (University of Cologne)

  • Bernd Timmermann

    (Max Planck Institute for Molecular Genetics)

  • Giovanna Marazzi

    (Stem Cells and Regenerative Medicine, ICAN-UMRS 1166, Université de Pierre et Marie Curie, Sorbonne Universités
    ICAN, Institute of Cardiometabolism and Nutrition)

  • David A. Sassoon

    (Stem Cells and Regenerative Medicine, ICAN-UMRS 1166, Université de Pierre et Marie Curie, Sorbonne Universités
    ICAN, Institute of Cardiometabolism and Nutrition)

  • Delphine Duprez

    (Sorbonne Universités, UPMC Univ Paris 06, CNRS UMR7622, IBPS-Developmental Biology Laboratory
    Inserm U1156, IBPS-Developmental Biology Laboratory)

  • Sigmar Stricker

    (Freie Universität Berlin
    Max Planck Institute for Molecular Genetics)

Abstract

Fibro-adipogenic progenitors (FAPs) are an interstitial cell population in adult skeletal muscle that support muscle regeneration. During development, interstitial muscle connective tissue (MCT) cells support proper muscle patterning, however the underlying molecular mechanisms are not well understood and it remains unclear whether adult FAPs and embryonic MCT cells share a common lineage. We show here that mouse embryonic limb MCT cells expressing the transcription factor Osr1, differentiate into fibrogenic and adipogenic cells in vivo and in vitro defining an embryonic FAP-like population. Genetic lineage tracing shows that developmental Osr1+ cells give rise to a subset of adult FAPs. Loss of Osr1 function leads to a reduction of myogenic progenitor proliferation and survival resulting in limb muscle patterning defects. Transcriptome and functional analyses reveal that Osr1+ cells provide a critical pro-myogenic niche via the production of MCT specific extracellular matrix components and secreted signaling factors.

Suggested Citation

  • Pedro Vallecillo-García & Mickael Orgeur & Sophie vom Hofe-Schneider & Jürgen Stumm & Verena Kappert & Daniel M. Ibrahim & Stefan T. Börno & Shinichiro Hayashi & Frédéric Relaix & Katrin Hildebrandt &, 2017. "Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development," Nature Communications, Nature, vol. 8(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01120-3
    DOI: 10.1038/s41467-017-01120-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-01120-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-01120-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01120-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.