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A long-range cis-regulatory element for class I odorant receptor genes

Author

Listed:
  • Tetsuo Iwata

    (Tokyo Institute of Technology)

  • Yoshihito Niimura

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo
    The University of Tokyo)

  • Chizuru Kobayashi

    (Graduate School of Life Science and Technology, Tokyo Institute of Technology)

  • Daichi Shirakawa

    (Graduate School of Life Science and Technology, Tokyo Institute of Technology)

  • Hikoyu Suzuki

    (Nihon BioData Corporation)

  • Takayuki Enomoto

    (Tokyo Institute of Technology)

  • Kazushige Touhara

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo
    The University of Tokyo)

  • Yoshihiro Yoshihara

    (The University of Tokyo
    RIKEN Brain Science Institute)

  • Junji Hirota

    (Tokyo Institute of Technology
    Graduate School of Life Science and Technology, Tokyo Institute of Technology)

Abstract

Individual olfactory sensory neurons express a single odorant receptor gene from either class I genes residing in a single cluster on a single chromosome or class II genes spread over multiple clusters on multiple chromosomes. Here, we identify an enhancer element for mouse class I genes, the J element, that is conserved through mammalian species from the platypus to humans. The J element regulates most class I genes expression by exerting an effect over ~ 3 megabases within the whole cluster. Deletion of the trans J element increases the expression frequencies of class I genes from the intact J allele, indicating that the allelic exclusion of class I genes depends on the activity of the J element. Our data reveal a long-range cis-regulatory element that governs the singular class I gene expression and has been phylogenetically preserved to retain a single cluster organization of class I genes in mammals.

Suggested Citation

  • Tetsuo Iwata & Yoshihito Niimura & Chizuru Kobayashi & Daichi Shirakawa & Hikoyu Suzuki & Takayuki Enomoto & Kazushige Touhara & Yoshihiro Yoshihara & Junji Hirota, 2017. "A long-range cis-regulatory element for class I odorant receptor genes," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00870-4
    DOI: 10.1038/s41467-017-00870-4
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