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Layer- and cell type-selective co-transmission by a basal forebrain cholinergic projection to the olfactory bulb

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  • Daniel T. Case

    (University of Pittsburgh School of Medicine
    Center for the Neural Basis of Cognition)

  • Shawn D. Burton

    (Center for the Neural Basis of Cognition
    Carnegie Mellon University
    University of Utah)

  • Jeremy Y. Gedeon

    (University of Pittsburgh School of Medicine)

  • Sean-Paul G. Williams

    (University of Pittsburgh School of Medicine)

  • Nathaniel N. Urban

    (University of Pittsburgh School of Medicine
    Center for the Neural Basis of Cognition
    Carnegie Mellon University)

  • Rebecca P. Seal

    (University of Pittsburgh School of Medicine
    Center for the Neural Basis of Cognition)

Abstract

Cholinergic neurons in the basal forebrain project heavily to the main olfactory bulb, the first processing station in the olfactory pathway. The projections innervate multiple layers of the main olfactory bulb and strongly influence odor discrimination, detection, and learning. The precise underlying circuitry of this cholinergic input to the main olfactory bulb remains unclear, however. Here, we identify a specific basal forebrain cholinergic projection that innervates select neurons concentrated in the internal plexiform layer of the main olfactory bulb. Optogenetic activation of this projection elicits monosynaptic nicotinic and GABAergic currents in glomerular layer-projecting interneurons. Additionally, we show that the projection co-expresses markers for GABAergic neurotransmission. The data thus implicate neurotransmitter co-transmission in the basal forebrain regulation of this inhibitory olfactory microcircuit.

Suggested Citation

  • Daniel T. Case & Shawn D. Burton & Jeremy Y. Gedeon & Sean-Paul G. Williams & Nathaniel N. Urban & Rebecca P. Seal, 2017. "Layer- and cell type-selective co-transmission by a basal forebrain cholinergic projection to the olfactory bulb," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00765-4
    DOI: 10.1038/s41467-017-00765-4
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