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Tango7 regulates cortical activity of caspases during reaper-triggered changes in tissue elasticity

Author

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  • Yunsik Kang

    (University of Wisconsin-Madison
    University of Wisconsin-Madison
    Oregon Health & Sciences University)

  • Sarah D. Neuman

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

  • Arash Bashirullah

    (University of Wisconsin-Madison
    University of Wisconsin-Madison
    University of Wisconsin-Madison)

Abstract

Caspases perform critical functions in both living and dying cells; however, how caspases perform physiological functions without killing the cell remains unclear. Here we identify a novel physiological function of caspases at the cortex of Drosophila salivary glands. In living glands, activation of the initiator caspase dronc triggers cortical F-actin dismantling, enabling the glands to stretch as they accumulate secreted products in the lumen. We demonstrate that tango7, not the canonical Apaf-1-adaptor dark, regulates dronc activity at the cortex; in contrast, dark is required for cytoplasmic activity of dronc during salivary gland death. Therefore, tango7 and dark define distinct subcellular domains of caspase activity. Furthermore, tango7-dependent cortical dronc activity is initiated by a sublethal pulse of the inhibitor of apoptosis protein (IAP) antagonist reaper. Our results support a model in which biological outcomes of caspase activation are regulated by differential amplification of IAP antagonists, unique caspase adaptor proteins, and mutually exclusive subcellular domains of caspase activity.

Suggested Citation

  • Yunsik Kang & Sarah D. Neuman & Arash Bashirullah, 2017. "Tango7 regulates cortical activity of caspases during reaper-triggered changes in tissue elasticity," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00693-3
    DOI: 10.1038/s41467-017-00693-3
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