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Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children

Author

Listed:
  • Ben S. Wendel

    (University of Texas at Austin)

  • Chenfeng He

    (University of Texas at Austin)

  • Mingjuan Qu

    (University of Texas at Austin
    Ludong University)

  • Di Wu

    (University of Texas at Austin)

  • Stefany M. Hernandez

    (University of Texas at Austin)

  • Ke-Yue Ma

    (University of Texas at Austin)

  • Eugene W. Liu

    (National Institutes of Health
    Center for Global Health)

  • Jun Xiao

    (ImmuDX, LLC)

  • Peter D. Crompton

    (National Institutes of Health)

  • Susan K. Pierce

    (National Institutes of Health)

  • Pengyu Ren

    (University of Texas at Austin)

  • Keke Chen

    (Wright State University)

  • Ning Jiang

    (University of Texas at Austin
    University of Texas at Austin)

Abstract

Accurately measuring antibody repertoire sequence composition in a small amount of blood is challenging yet important for understanding repertoire responses to infection and vaccination. We develop molecular identifier clustering-based immune repertoire sequencing (MIDCIRS) and use it to study age-related antibody repertoire development and diversification before and during acute malaria in infants (

Suggested Citation

  • Ben S. Wendel & Chenfeng He & Mingjuan Qu & Di Wu & Stefany M. Hernandez & Ke-Yue Ma & Eugene W. Liu & Jun Xiao & Peter D. Crompton & Susan K. Pierce & Pengyu Ren & Keke Chen & Ning Jiang, 2017. "Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00645-x
    DOI: 10.1038/s41467-017-00645-x
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