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A prophage tail-like protein is deployed by Burkholderia bacteria to feed on fungi

Author

Listed:
  • Durga Madhab Swain

    (National Institute of Plant Genome Research)

  • Sunil Kumar Yadav

    (National Institute of Plant Genome Research)

  • Isha Tyagi

    (National Institute of Plant Genome Research)

  • Rahul Kumar

    (National Institute of Plant Genome Research)

  • Rajeev Kumar

    (National Institute of Plant Genome Research)

  • Srayan Ghosh

    (National Institute of Plant Genome Research)

  • Joyati Das

    (National Institute of Plant Genome Research)

  • Gopaljee Jha

    (National Institute of Plant Genome Research)

Abstract

Some bacteria can feed on fungi, a phenomenon known as mycophagy. Here we show that a prophage tail-like protein (Bg_9562) is essential for mycophagy in Burkholderia gladioli strain NGJ1. The purified protein causes hyphal disintegration and inhibits growth of several fungal species. Disruption of the Bg_9562 gene abolishes mycophagy. Bg_9562 is a potential effector secreted by a type III secretion system (T3SS) and is translocated into fungal mycelia during confrontation. Heterologous expression of Bg_9562 in another bacterial species, Ralstonia solanacearum, confers mycophagous ability in a T3SS-dependent manner. We propose that the ability to feed on fungi conferred by Bg_9562 may help the bacteria to survive in certain ecological niches. Furthermore, considering its broad-spectrum antifungal activity, the protein may be potentially useful in biotechnological applications to control fungal diseases.

Suggested Citation

  • Durga Madhab Swain & Sunil Kumar Yadav & Isha Tyagi & Rahul Kumar & Rajeev Kumar & Srayan Ghosh & Joyati Das & Gopaljee Jha, 2017. "A prophage tail-like protein is deployed by Burkholderia bacteria to feed on fungi," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00529-0
    DOI: 10.1038/s41467-017-00529-0
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