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Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction

Author

Listed:
  • M. T. Jeena

    (Ulsan National Institute of Science and Technology (UNIST))

  • L. Palanikumar

    (Ulsan National Institute of Science and Technology (UNIST))

  • Eun Min Go

    (Ulsan National Institute of Science and Technology (UNIST))

  • Inhye Kim

    (Chungnam National University)

  • Myoung Gyun Kang

    (Ulsan National Institute of Science and Technology (UNIST))

  • Seonik Lee

    (Ulsan National Institute of Science and Technology (UNIST))

  • Sooham Park

    (Ulsan National Institute of Science and Technology (UNIST))

  • Huyeon Choi

    (Ulsan National Institute of Science and Technology (UNIST))

  • Chaekyu Kim

    (Ulsan National Institute of Science and Technology (UNIST))

  • Seon-Mi Jin

    (Chungnam National University)

  • Sung Chul Bae

    (Ulsan National Institute of Science and Technology (UNIST))

  • Hyun Woo Rhee

    (Ulsan National Institute of Science and Technology (UNIST))

  • Eunji Lee

    (Chungnam National University)

  • Sang Kyu Kwak

    (Ulsan National Institute of Science and Technology (UNIST))

  • Ja-Hyoung Ryu

    (Ulsan National Institute of Science and Technology (UNIST))

Abstract

Achieving spatiotemporal control of molecular self-assembly associated with actuation of biological functions inside living cells remains a challenge owing to the complexity of the cellular environments and the lack of characterization tools. We present, for the first time, the organelle-localized self-assembly of a peptide amphiphile as a powerful strategy for controlling cellular fate. A phenylalanine dipeptide (FF) with a mitochondria-targeting moiety, triphenyl phosphonium (Mito-FF), preferentially accumulates inside mitochondria and reaches the critical aggregation concentration to form a fibrous nanostructure, which is monitored by confocal laser scanning microscopy and transmission electron microscopy. The Mito-FF fibrils induce mitochondrial dysfunction via membrane disruption to cause apoptosis. The organelle-specific supramolecular system provides a new opportunity for therapeutics and in-depth investigations of cellular functions.

Suggested Citation

  • M. T. Jeena & L. Palanikumar & Eun Min Go & Inhye Kim & Myoung Gyun Kang & Seonik Lee & Sooham Park & Huyeon Choi & Chaekyu Kim & Seon-Mi Jin & Sung Chul Bae & Hyun Woo Rhee & Eunji Lee & Sang Kyu Kwa, 2017. "Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00047-z
    DOI: 10.1038/s41467-017-00047-z
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