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Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection

Author

Listed:
  • Zhipeng Xu

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Lei Xu

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Wei Li

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Xin Jin

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Xian Song

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Xiaojun Chen

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Jifeng Zhu

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Sha Zhou

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Yong Li

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Weiwei Zhang

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Xiaoxiao Dong

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Xiaowei Yang

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Feng Liu

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

  • Hui Bai

    (Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University)

  • Qi Chen

    (Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University)

  • Chuan Su

    (Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University)

Abstract

The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen infection. Here we show with mouse models of helminth Schistosoma japonicum infection and heat-inactivated Mycobacterium tuberculosis stimulation that SR-A is regulated by pathogens and suppresses IRF5 nuclear translocation by direct interaction. Reduced abundance of nuclear IRF5 shifts macrophage polarization from M1 towards M2, which subsequently switches T-helper responses from type 1 to type 2. Our study identifies a role for SR-A as an innate PRR in regulating adaptive immune responses.

Suggested Citation

  • Zhipeng Xu & Lei Xu & Wei Li & Xin Jin & Xian Song & Xiaojun Chen & Jifeng Zhu & Sha Zhou & Yong Li & Weiwei Zhang & Xiaoxiao Dong & Xiaowei Yang & Feng Liu & Hui Bai & Qi Chen & Chuan Su, 2017. "Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms16035
    DOI: 10.1038/ncomms16035
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