Author
Listed:
- David E. J. Waddington
(A.A. Martinos Center for Biomedical Imaging
ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney
Harvard University)
- Mathieu Sarracanie
(A.A. Martinos Center for Biomedical Imaging
Harvard University
Harvard Medical School)
- Huiliang Zhang
(Harvard University
Harvard-Smithsonian Center for Astrophysics)
- Najat Salameh
(A.A. Martinos Center for Biomedical Imaging
Harvard University
Harvard Medical School)
- David R. Glenn
(Harvard University
Harvard-Smithsonian Center for Astrophysics)
- Ewa Rej
(ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney)
- Torsten Gaebel
(ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney)
- Thomas Boele
(ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney)
- Ronald L. Walsworth
(Harvard University
Harvard-Smithsonian Center for Astrophysics)
- David J. Reilly
(ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney)
- Matthew S. Rosen
(A.A. Martinos Center for Biomedical Imaging
Harvard University
Harvard Medical School)
Abstract
Nanodiamonds are of interest as nontoxic substrates for targeted drug delivery and as highly biostable fluorescent markers for cellular tracking. Beyond optical techniques, however, options for noninvasive imaging of nanodiamonds in vivo are severely limited. Here, we demonstrate that the Overhauser effect, a proton–electron polarization transfer technique, can enable high-contrast magnetic resonance imaging (MRI) of nanodiamonds in water at room temperature and ultra-low magnetic field. The technique transfers spin polarization from paramagnetic impurities at nanodiamond surfaces to 1H spins in the surrounding water solution, creating MRI contrast on-demand. We examine the conditions required for maximum enhancement as well as the ultimate sensitivity of the technique. The ability to perform continuous in situ hyperpolarization via the Overhauser mechanism, in combination with the excellent in vivo stability of nanodiamond, raises the possibility of performing noninvasive in vivo tracking of nanodiamond over indefinitely long periods of time.
Suggested Citation
David E. J. Waddington & Mathieu Sarracanie & Huiliang Zhang & Najat Salameh & David R. Glenn & Ewa Rej & Torsten Gaebel & Thomas Boele & Ronald L. Walsworth & David J. Reilly & Matthew S. Rosen, 2017.
"Nanodiamond-enhanced MRI via in situ hyperpolarization,"
Nature Communications, Nature, vol. 8(1), pages 1-8, April.
Handle:
RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15118
DOI: 10.1038/ncomms15118
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