IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15118.html
   My bibliography  Save this article

Nanodiamond-enhanced MRI via in situ hyperpolarization

Author

Listed:
  • David E. J. Waddington

    (A.A. Martinos Center for Biomedical Imaging
    ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney
    Harvard University)

  • Mathieu Sarracanie

    (A.A. Martinos Center for Biomedical Imaging
    Harvard University
    Harvard Medical School)

  • Huiliang Zhang

    (Harvard University
    Harvard-Smithsonian Center for Astrophysics)

  • Najat Salameh

    (A.A. Martinos Center for Biomedical Imaging
    Harvard University
    Harvard Medical School)

  • David R. Glenn

    (Harvard University
    Harvard-Smithsonian Center for Astrophysics)

  • Ewa Rej

    (ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney)

  • Torsten Gaebel

    (ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney)

  • Thomas Boele

    (ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney)

  • Ronald L. Walsworth

    (Harvard University
    Harvard-Smithsonian Center for Astrophysics)

  • David J. Reilly

    (ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney)

  • Matthew S. Rosen

    (A.A. Martinos Center for Biomedical Imaging
    Harvard University
    Harvard Medical School)

Abstract

Nanodiamonds are of interest as nontoxic substrates for targeted drug delivery and as highly biostable fluorescent markers for cellular tracking. Beyond optical techniques, however, options for noninvasive imaging of nanodiamonds in vivo are severely limited. Here, we demonstrate that the Overhauser effect, a proton–electron polarization transfer technique, can enable high-contrast magnetic resonance imaging (MRI) of nanodiamonds in water at room temperature and ultra-low magnetic field. The technique transfers spin polarization from paramagnetic impurities at nanodiamond surfaces to 1H spins in the surrounding water solution, creating MRI contrast on-demand. We examine the conditions required for maximum enhancement as well as the ultimate sensitivity of the technique. The ability to perform continuous in situ hyperpolarization via the Overhauser mechanism, in combination with the excellent in vivo stability of nanodiamond, raises the possibility of performing noninvasive in vivo tracking of nanodiamond over indefinitely long periods of time.

Suggested Citation

  • David E. J. Waddington & Mathieu Sarracanie & Huiliang Zhang & Najat Salameh & David R. Glenn & Ewa Rej & Torsten Gaebel & Thomas Boele & Ronald L. Walsworth & David J. Reilly & Matthew S. Rosen, 2017. "Nanodiamond-enhanced MRI via in situ hyperpolarization," Nature Communications, Nature, vol. 8(1), pages 1-8, April.
  • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15118
    DOI: 10.1038/ncomms15118
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15118
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/ncomms15118?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15118. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.