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Transiently antigen-primed B cells return to naive-like state in absence of T-cell help

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  • Jackson S. Turner

    (University of Michigan Medical School)

  • Matangi Marthi

    (University of Michigan Medical School)

  • Zachary L. Benet

    (University of Michigan Medical School)

  • Irina Grigorova

    (University of Michigan Medical School)

Abstract

The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells that are continuously exposed to self-antigens. However, intravital imaging suggests that early B-cell recognition of large foreign antigens may be transient. Whether B cells are tolerized or can be recruited into humoural immune responses following such encounters is not clear. Here we show that in the presence of T-cell help, single transient antigen acquisition is sufficient to recruit B cells into the germinal centre and induce memory and plasma cell responses. In the absence of T-cell help, transiently antigen-primed B cells do not undergo apoptosis in vivo; they return to quiescence and are recruited efficiently into humoural responses upon reacquisition of antigen and T-cell help.

Suggested Citation

  • Jackson S. Turner & Matangi Marthi & Zachary L. Benet & Irina Grigorova, 2017. "Transiently antigen-primed B cells return to naive-like state in absence of T-cell help," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15072
    DOI: 10.1038/ncomms15072
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